Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism - Food & Drink Intake
Pain
Central Nervous System (CNS)
Neurodegeneration
Sensory system
Motor control
Mood Disorders
Other disorders
Muscular system
Joints
Metabolism
Cross-disciplinary subjects
Preclinical studies and opioids: role in crisis management in the United States Authors
IV Cheretaev, EN Chuyan, MY Ravaeva, VF Shulgin
Lab
Tavrida Academy (structural unit) FSAEI of HE, V.I. Vernadsky Crimean Federal University, Simferopol, Russia
Journal
International Research Journal
Abstract
The paper presents the results of studying the effect of 1-hydroxy-1,1-ethylidene diphosphonic acid and bis(2-pyridyl-1,2,4-triazolyl-3) propane with doses of 5, 50, 100 and 200 mg/kg on the pain sensitivity of rat females. The experiments were conducted on 100 Wistar female rats on acute thermal (tail-flick, hot plate) and mechanical pain test models (Randall-Selitto test). It was found that 1-hydroxy-1,1-ethylidene diphosphonic acid has a clear analgesic effect with thermal effects in doses of 5 and 200 mg/kg, and mechanical pain effects with a dose of 50 mg/kg; bis (2-pyridyl-1,2,4-triazolyl-3) propane in the tail-flick test with doses of 5 and 50 mg/kg, in the hot plate test, with the dose of 50 mg/kg, in the Randall-Selittto test, with a dose of 50 mg/kg.
BIOSEB Instruments Used:
Rodent pincher - analgesia meter (BIO-RP-M)
