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Pain - Spontaneous Pain - Postural Deficit

Bioseb launched the first Dynamic Weight Distribution (DWB) in collaboration with Sherbrooke University (Canada), in 2010, for studying inflammatory pain in rodents. Since then we continue to innovate with systems designed to evaluate spontaneous pain and postural alterations. By detecting subtle behavioral changes, our devices contribute to understanding musculoskeletal pain and nerve injury models. Read more >

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Dynamic Weight Bearing 2.0

The advanced version of our Dynamic Weight Bearing Test for rodents (rats and mice) allows for faster paw identification,...

Static Weight Bearing Touch: Incapacitance Test

An easy and non pain-inducing solution for assessing the level of discomfort (incapacitance) in the injured paw of a small...

Kinetic Weight Bearing

A unique device that provides automated measurement of weight bearing and force distribution over time during voluntary...

Dynamic Weight Bearing 2.0 – Postural Module...

Expand Your Analysis with Advanced Postural and Locomotor Calculations

BIOSEB’s renowned Dynamic Weight...

Bioseb CIS Software

A NEW software for increasing the repeatability of nociceptive tests: by recording the reflex respond the software help the...

Description

Bioseb's instruments are trusted by researchers worldwide to study spontaneous pain and postural deficits, as demonstrated in numerous peer-reviewed studies. These tools are pivotal for advancing the understanding of chronic pain and motor impairments in preclinical models. Here are examples of key studies using our innovative solutions in pain research.

Bioseb’s specialized instrumentation enables researchers to quantify spontaneous pain behaviors and postural alterations in rodent models. These systems reveal subtle yet significant changes in animal posture, weight distribution, and mobility—key indicators of discomfort or pain resulting from musculoskeletal issues, nerve injuries, and chronic pain conditions.

By objectively measuring changes in weight bearing, force distribution, and spontaneous pain-related behaviors, these tools facilitate a comprehensive understanding of pain pathophysiology. Such insights are vital for developing and assessing new analgesics, rehabilitation strategies, and therapeutic interventions that target underlying pain mechanisms.

FAQ

1. What types of pain conditions can be studied with these instruments?

These devices are suited for evaluating pain arising from musculoskeletal disorders, nerve injury models, inflammatory conditions, and post-surgical pain. They provide critical insights into both acute and chronic forms of spontaneous pain and associated postural deficits.

2. Why focus on weight bearing and postural changes to assess pain?

Altered weight distribution and postural shifts often occur when an animal experiences pain. These subtle changes can serve as sensitive indicators of discomfort before more overt behaviors appear. By quantifying these changes objectively, researchers gain early, reliable data on the presence and severity of pain.

3. How do these instruments minimize animal stress and observer bias?

Our systems are designed with animal welfare in mind. For example, the Static Weight Bearing Touch test (Incapacitance Test) and Dynamic Weight Bearing setup reduce handling stress. Automated data acquisition and advanced image processing minimize human intervention, ensuring accurate and reproducible results while minimizing observer bias.

4. Can these data be integrated with other physiological or behavioral measurements?

Yes. Results from weight-bearing and postural assessments can be exported in standard formats compatible with various data analysis software. Researchers can easily combine these measurements with other endpoints, such as imaging, electrophysiology, or biochemical assays, to form a more comprehensive understanding of pain mechanisms.

5. How does Bioseb CIS Software improve reproducibility?

The Bioseb CIS Software standardizes data acquisition and analysis, reducing variability between sessions and operators. By capturing reflex responses and automating key calculations, CIS improves data consistency, helping researchers confidently draw conclusions from their experiments.

6. What support and training does Bioseb provide?

Technical support from Bioseb is available upon request, with services tailored to the specific needs of your equipment. This may include guidance for installation, training on hardware and software, or help with optimizing experimental protocols. For further details or to request assistance, please reach out through our contact form.