Pain - Mechanical Allodynia / Hyperalgesia

Our Electronic Von Frey - Wireless and the Electronic Von Frey 5 with Embedded Camera are both highly accurate and automated solutions for quantifying mechanical sensitivity thresholds in mice and rats. They provide objective data and reduce observer bias by applying controlled, incremental force to the animal’s paw and detecting withdrawal responses.

The Modular Holder Cages for Rats and Mice coupled with the Elevated Metal Mesh Stand create a standardized, comfortable testing environment. These accessories help minimize stress for the animal, improve handling efficiency, and provide easy access for the application of stimuli with instruments like the Electronic Von Frey or Von Frey Filaments.

We offer several complementary instruments:

Rodent Pincher - Wireless Analgesia Meter: An alternative to the Randall-Selitto test, this device uses a pincher mechanism to apply pressure and measure the animal’s threshold. SMALGO (Small Animal Algometer - Wireless): Designed specifically for small rodents, SMALGO uses controlled pressure to evaluate pain sensitivity with high precision. ALGOKIT Analgesimeter - Wireless: A versatile system that can be configured for various force-based tests, providing flexible and quantitative sensory testing.

Yes. The Vetalgo Algometer for Big Mammals is a wireless and non-invasive device suitable for larger animals, such as canines, felines, or agricultural species. This tool is beneficial in veterinary research and clinical settings, providing quick and accurate assessments of mechanical pain thresholds.

Von Frey Filaments remain a well-established, manual method for measuring mechanical sensitivity. They offer a cost-effective, simple solution for initial screenings or to complement electronic measurements. Additionally, the Rat Paw Pressure test applies uniformly increasing pressure to quantify pain thresholds, serving as a classic, reliable test for mechanical hyperalgesia.

Our Plethysmometer can measure paw volume changes related to inflammation, complementing your mechanical sensitivity data. By combining plethysmometry with tools like the Electronic Von Frey or Rodent Pincher, you gain a more comprehensive understanding of both inflammatory processes and the corresponding alterations in pain sensitivity.

The Electronic Von Frey 5 with Embedded Camera allows real-time visualization and recording of the test session. This documentation aids in reviewing tests afterward for quality control, training new personnel, and ensuring consistent, unbiased scoring of animal responses.

Yes. Most Bioseb instruments offer exportable data in common formats. This feature makes it easy to integrate readings from the Electronic Von Frey, ALGOKIT, SMALGO, or Vetalgo systems with external data analysis tools, imaging studies, electrophysiological recordings, or molecular assays, providing a holistic view of your experimental outcomes.

Our instruments are robust, user-friendly, and designed for repeated measurements over long durations. Their reliability makes them ideal for chronic pain models, enabling you to assess the efficacy of analgesics, track changes over time, and monitor disease progression or recovery in the same group of animals. However, it should be noted that individual housing can be stressful for animals and requires prior approval from the appropriate regulatory authorities in the laboratory.

On request, Bioseb provides technical support and training services tailored to the requirements of each instrument. These services cover installation, training on hardware and software, and protocol optimization, based on the complexity of the device. For additional details or to arrange support, please reach out via our contact form.