Chronic pain Scientific Publications

Latest publication 01/01/2025

Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seek

Abstract Alcohol use disorder (AUD) and chronic pain are complex and debilitating conditions that are highly comorbid. Greater than 50% of...

Array
(
    [id_prestablog_news] => 2009
    [id_shop] => 1
    [date] => 2025-01-01 00:00:00
    [date_modification] => 2025-01-01 00:00:00
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 3692
    [id_lang] => 1
    [title] => Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seek
    [paragraph] => Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice
    [content] => 
Authors
Mitchell A Nothem, Christine M Side, Simon C Tran, Anaahat Brar, Lauren A Buck, Jacqueline M Barker

 Lab

Journal
bioRxiv
Abstract
Abstract
Alcohol use disorder (AUD) and chronic pain are complex and debilitating conditions that are highly comorbid. Greater than 50% of individuals with AUD have chronic pain. Clinical data suggest that people with chronic pain are more likely to report using alcohol to manage chronic pain, and that magnitude of pain is correlated with relapse probability after a period of abstinence. These data led to the hypothesis that pain can drive ethanol seeking and reinstatement in a rodent model of chronic neuropathic pain. A conditioned place preference (CPP) paradigm was used to model ethanol seeking in male C57BL6J mice with a spared nerve injury (SNI). Mice were conditioned with doses of ethanol previously found to reverse pain behavior (0.5g/kg). Mice with and without SNI showed similar magnitudes of ethanol CPP and rates of extinction. To investigate pain-induced relapse-related behavior, mice underwent reinstatement testing following painful mechanical stimulation which was delivered at either a “moderate” or “high” intensity immediately prior to return to the CPP apparatus. “Moderate” painful hindpaw stimulation reinstated ethanol seeking behavior in SNI-injured, but not sham, mice, while “high” intensity stimulation reinstated ethanol seeking in mice regardless of injury status. These data suggest that males in chronic pain are more susceptible reinstatement of ethanol seeking following a painful experience.

Keywords/Topics
Chronic pain
BIOSEB Instruments Used:
Dynamic Weight Bearing 2.0 (BIO-DWB-DUAL)
    [meta_description] => 
    [meta_keywords] => https://www.biorxiv.org/content/10.1101/2025.04.10.648244.abstract
    [meta_title] => 
    [link_rewrite] => Chronic-pain-increases-sensitivity-to-pain-induced-reinstatement-of-ethanol-seeking-in-male-mice
    [actif_langue] => 1
    [read] => 7
    [count_comments] => 0
    [id] => 2009
    [categories] => Array
        (
            [30] => Array
                (
                    [id_prestablog_categorie] => 30
                    [title] => Chronic pain
                    [link_rewrite] => Chronic-pain
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Chronic pain increases sensitivity to pain-induced reinstatement of ethanol seeking in male mice
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1216] => Array
                (
                    [name] => Dynamic Weight Bearing 2.0
                    [description_short] => 
The advanced version of our Dynamic Weight Bearing Test for rodents (rats and mice) allows for faster paw identification, based on a video solution taking advantage of the most advanced algorithms of morphologic analysis, weight distribution and postural changes in dynamic conditions. An efficient and advanced alternative to traditional incapacitance tests (i.e. the paw pressure test or the force plate test) for assessing pain sensitivity in your research on analgesia, hyperalgesia and nociception involving rats and mice, including work on osteoarthritis, bone cancer, analgesic substances, Parkinson disease, allodynia...

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/en/pain-spontaneous-pain-postural-deficit/1216-dynamic-weight-bearing-20.html
                )

        )

)
1