Hot & Cold Perception Scientific Publications

Latest publication 03/01/2026

Behavioral Thermoceptive Responses and Morphologic Correlates in Mouse Models of

Thermal gradient testing revealed preserved temperature preference in CMT1A and HNPP mice but significantly altered behavior in aged animals, which...

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    [title] => Behavioral Thermoceptive Responses and Morphologic Correlates in Mouse Models of
    [paragraph] => Behavioral Thermoceptive Responses and Morphologic Correlates in Mouse Models of CMT1A- HNPP- and Aging
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Authors
Vaibhav Oberoi, James O. Campbell, Nelson Akpabli-Tsigbe, Fatima Imran, Silvano Bond, Sara Ngo Tenlep, Charles D. Brennan, Meifang Wang, Smita Saxena, Kathryn R. Moss, De-Pei Li, W. David Arnold, Ryan Castoro

 Lab

Journal
Journal of the Peripheral Nervous System
Abstract
Thermal gradient testing revealed preserved temperature preference in CMT1A and HNPP mice but significantly altered behavior in aged animals, which spent less time in warmer zones. Hot plate testing showed prolonged times to nocifensive behavior in aged and CMT1A mice, whereas HNPP mice exhibited variable responses. IENFD was markedly reduced in aged mice but preserved in CMT1A and HNPP. DRG analysis revealed smaller soma diameters and reduced proportions of TRPV1-positive Aδ neurons in aged mice, while CMT1A animals maintained normal morphology.
Keywords/Topics
aging; charcot–marie–tooth disease; hereditary neuropathy with liability to pressure palsies; thermoception
BIOSEB Instruments Used:
Cold Hot Plate Test (BIO-CHP),Thermal Gradient Test 2.0 (BIO-GRADIENT2)
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For testing animal's thermal sensitivity to pain resulting from exposure to heat or cold: the Cold Hot Plate is an innovative instrument opening new investigation fields for your analgesia and nociception research, and a useful tool for analgesic drug screening using rats or mice models.

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New and improved! The operator-independent Thermal Gradient Test used to show favorite temperature and thermal comfort threshold on rodents (mouse and rat) freely moving on a plate offering a temperature gradient has a new software application with enhanced function and user experience. BIO-GRADIENT2 is an innovative tool for analgesic drug screening and research on thermal nociception and sensitivity.

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