General muscular system Scientific Publications

Latest publication 12/19/2025

Estradiol rescues male hydroxyl radical-mediated Charcot-Marie-Tooth 2Z by Morc2

Charcot–Marie–Tooth disease type 2Z (CMT2Z) is an inherited axonal neuropathy caused by haploinsufficiency of microrchidia CW-type...

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    [title] => Estradiol rescues male hydroxyl radical-mediated Charcot-Marie-Tooth 2Z by Morc2
    [paragraph] => Estradiol rescues male hydroxyl radical-mediated Charcot-Marie-Tooth 2Z by Morc2a stabilization through autophagy inhibition in a murine model
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Authors
Kim, Ji Won, Nam, Soo Hyun, Lee, Geon Seong, Chung, Hye Yoon, Kim, Eun Young, Han, Jeong Pil, Jang, Jae-Hyung, Choi, Byung-Ok, Yeom, Su Cheong

 Lab

Journal
Acta Neuropathologica
Abstract
Charcot–Marie–Tooth disease type 2Z (CMT2Z) is an inherited axonal neuropathy caused by haploinsufficiency of microrchidia CW-type zinc finger
Keywords/Topics
Charcot-Marie-Tooth type2Z; Estradiol; Hydroxyl radical; MORC2 haploinsufficiency; Neuromuscular regeneration
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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