Anxiety Scientific Publications

Latest publication 07/14/2026

Multi-generational exposure to glyphosate and glyphosate-based herbicides induce

Environmental and occupational glyphosate exposure is associated with a variety of adverse health and neurobehavioral effects in children and...

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    [title] => Multi-generational exposure to glyphosate and glyphosate-based herbicides induce
    [paragraph] => Multi-generational exposure to glyphosate and glyphosate-based herbicides induces neurobehavioral alterations in Sprague-Dawley rats
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Authors
I. Menghetti, I. Thiara, S. Panzacchi, L. Falcioni, R. Giovannini, M. Iuliani, M. Manservigi, S. Nanni, D. Sgargi, V. Strollo, M.J. Perry, P. J. Landrigan, D.R. Smith, D. Mandrioli

Lab
Journal
Abstract
Environmental and occupational glyphosate exposure is associated with a variety of adverse health and neurobehavioral effects in children and adults, such as anxiety and autism spectrum disorders. Here we used a Sprague-Dawley rat model of transgenerational environmental exposure to glyphosate or two glyphosate-based herbicides (Roundup Bioflow and Ranger Pro), at targeted daily oral doses of 0, 0.5 (EU ADI), 5, or 50 (EU NOAEL) mg/kg bw/day of glyphosate, starting on gestational day 6 in F0 pregnant dams and continuing in F1 generation postnatally through pregnancy and lactation and postnatally in the F2 generation through 1 year of age. Neurobehavioral performance was assessed at 1 year of age using the open field test of behavioral activity, the balance beam test of gross motor coordination, the grip strength test of fore- and hindlimb neuromuscular tone, the passive avoidance test of short-term memory and the Irwin test to detect behavioral/physiological changes. Findings show that all three compounds tested altered behavioral reactivity and open field exploration consistent with increased anxiety in a dose-response fashion, though the Roundup Bioflow and/or Ranger Pro formulations caused greater anxiety-like behaviors than glyphosate alone; when sex-based differences were present, males were more affected than females. Moreover, Roundup Bioflow and/or Ranger Pro, but not glyphosate alone altered gross motor coordination and neuromuscular tone. There were no effects of any formulation on short term memory to avoid an aversive stimulus in the passive avoidance test. These results demonstrate that multi-generational exposure to glyphosate and glyphosate-based herbicides produces significant neurobehavioral impairments and increased anxiety-like behaviors in Sprague-Dawley (SD) rats at doses that are currently considered “safe”, substantiating concerns for the adverse health effects of environmental and occupational applications of these commonly used herbicides.
Keywords/Topics
multi-generational exposure; neurobehavioral alterations; neurobehavioral effects; transgenerational environmental exposure; f1 generation; neurobehavioral performance; behavioral activity; behavioral physiological changes; altered behavioral reactivity; open field exploration
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
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