General metabolism Scientific Publications

Latest publication 01/01/2026

The Prospect of Combined Supplementation of Sugar and Creatine as a Core Formula

Compound sugars (Cs) and creatine (Cr) have the potential to enhance exercise endurance; however, the mechanisms underlying their effects and the...

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    [title] => The Prospect of Combined Supplementation of Sugar and Creatine as a Core Formula
    [paragraph] => The Prospect of Combined Supplementation of Sugar and Creatine as a Core Formulation for Sports Drinks- The Perspectives of Athletic Performance and Stability
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Authors
Zhang, Yue, Liao, Hui, Zhu, Song, Zhao, Yanting, Li, Fei, Li, Xiang, Li, Yue

 Lab
* Author to whom correspondence should be addressed.; Author to whom correspondence should be addressed.; Primary and Hospital Care
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Abstract
Compound sugars (Cs) and creatine (Cr) have the potential to enhance exercise endurance; however, the mechanisms underlying their effects and the stability of their formulations still require further investigation. This study investigated the effects of Cs and Cr supplementation on exercise performance in C57BL/6 mice, as well as the processing properties of Cs and Cr powder. The exhaustion time, serum fatigue indices, creatine contents, the morphology of muscle tissue in mice were determined. The results demonstrated that combined supplementation of sugar and creatine (Cs-Cr, Cs 6.2 mg/g + Cr 1.0 mg/g) could significantly increase exhaustion time and forelimb grip strength and reduce the levels of lactate and blood urea nitrogen by 22.3% and 25.86%, respectively. In addition, Cs-Cr supplementation increased muscle mass and muscle fiber density in exercise-trained mice and thus alleviated muscle damage caused by exercise. However, Cs-Cr powder exhibits poor stability during processing. Xanthan gum and locust bean gum (m/m = 6:4) has been demonstrated to increase the stability and viscosity of Cs-Cr beverages. Moreover, the addition of 1.5% CaSiO3 also reduced the caking of the powder and increased the stability of the product. This study provides a theoretical basis for the application of Cs-Cr in a functional solid beverage.
Keywords/Topics
mice; forelimb grip strength; exercise-trained mice; combined supplementation; sugar; creatine; sports drinks; exercise endurance; their effects; their formulations
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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