
A unique setup for the automation of the Open Field test for rats and mice : 3D-camera based technology is now capable of direct height...
A unique setup for the automation of the Open Field test for rats and mice : 3D-camera based technology is now capable of direct height...
Discover our productsAn easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e....
Discover our productsThe BIOSEB Spontaneous Activity Wheel is an easy way to quantify rodent voluntary activity in their home cage environment. The embedded...
Discover our productsThe uncomplicated way to monitor rodent activity over several days from their home cage without manual effort. Based only on weight...
Discover our productsThese small animal treadmills are used for forced exercise training and accurate testing of fatigue in rodents. The control unit now...
Discover our productsRotarod provides an easy way to test the motor activity in rodents (mouse or rat) - an ideal solution for studying central nervous...
Discover our productsFor testing animal's thermal sensitivity to pain resulting from exposure to heat or cold: the Cold Hot Plate is an innovative instrument...
Discover our productsAn operator independent test to study pain thresholds in rodents (mouse and rat) by assessing temperature preference (thermal comfort...
Discover our productsNew and improved! The operator-independent Thermal Gradient Test used to show favorite temperature and thermal comfort threshold on...
Discover our productsParticularly sensitive for studying the analgesic properties of pharmacological substances
Discover our productsThe advanced version of our Dynamic Weight Bearing Test for rodents (rats and mice) allows for faster paw identification, based on a...
Discover our productsA unique device that provides automated measurement of weight bearing and force distribution over time during voluntary gait....
Discover our productsA NEW software for increasing the repeatability of nociceptive tests: by recording the reflex respond the software help the operator to...
Discover our productsA quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats). Now wireless, to be free from annoying...
Discover our productsThe latest evolution of Bioseb's Electronic Von Frey instrument for determining the mechanical sensitivity threshold in rodents (rats...
Discover our productsNew ROBUST and modular cages to gently hold rodents (rats or mice) during nociceptive and analgesic tests including Hargreaves and Von...
Discover our productsAn economical and versatile solution for when flexible quantitative sensory testing (QST) is needed: built around our state-of-the-art...
Discover our productsDedicated to small animals, like mice and rats, Smalgo is a pressure-based analgesimeter designed for easy assessment of sensitivity...
Discover our productsBioseb's version 5 of the Tail Suspension Test system, based on both strain sensors and video acquisition, is the only fully automatic...
Discover our productsNEW ! A complete (hardware + software), dedicated and automated solution for the Elevated Plus Maze test, featuring unprecedented...
Discover our productsA unique setup for the automation of the Open Field test for rats and mice : 3D-camera based technology is now capable of direct height...
Discover our productsOpen-field test - ARENA ONLY - used to evaluate of animal's basal activity and its evolution for rodents (rats and mice) in response to...
Discover our productsThe new Forced Swimming Test system from Bioseb uses a dual approach: Combining a double input from vibrations and video, the TYC...
Discover our productsA brand new innovative setup for the automation of the Novel Object Recognition Test : 3D-camera based technology is now capable of...
Discover our productsOpen-field test - ARENA ONLY - used to evaluate of animal's basal activity and its evolution for rodents (rats and mice) in response to...
Discover our productsAn entirely modular experimental enclosure designed to conduct operant conditioning procedures (e.g. food reinforcement, DMTS, conflict...
Discover our productsA standard experimental chamber for automated or manual assessment of conditioned place preference and aversion in rodents (rats or...
Discover our productsThe ETH-401 is a bridge amplifier for various transducers that provides four channels of excitation power, gain, and noise filtration: an...
Discover our productsThe IX-118 is a fast 100 Khz, high-resolution data acquisition system suitable for most data recording studies in research laboratories...
Discover our productsThe ETH-256 is a 2 channels high performance, general-purpose life science research amplifier, allowing faithful low noise recording of...
Discover our productsFull-featured multi-channel stimulator for neuromuscular stimulation
Discover our productsThe From now On POPULAR IX-214 Unit is the perfect rugged, reliable, four-channel data recording unit, engineered to take years...
Discover our productsThe OXYLET system - Physiocage is a modular system allowing the integration of respiratory metabolism (O2 consumption / CO2...
Discover our productsInnovative and appropriate equipment for measuring food/liquid consumption and correlated motor activity in rats and mice
Discover our productsAn economical, high performance Oxygen and Carbon Dioxide Analyzer with sampling rates fast enough to measure breath-to-breath samples...
Discover our productsA fast and accurate algometer based on an instrumented pincher as an alternative to the Randall-Selitto test: This new analgesia meter developed by Bioseb following Luis-Delgado et al. (2005) allows accurate nociceptive tests to measure mechanical pain threshold on rat or mouse limbs with minimal constraint. Now wireless, to be free from annoying cables!
Presentation
Bioseb's 'Rodent Pincher' algometer allows calibrated forceps to induce quantifiable mechanical stimulation in the animal (rats or mice) on a linear scale. The most suitable protocol was experimented by determining the effects of 3 repetitive measurements on the 2 hindpaws, respectively over long-term (9 days), mid-term (1 day) and short-term (2 hours). It was primarily developed as an analgesimeter/algometer (analgesia measurement instrument) for nociceptive tests. In this specific use, the Rodents Pincher not only represents an alternative to the 'RANDALL & SELITTO' test - but also presents the following advantages when compared to the classical test:
• More ethical handling, less stressful for the animal (rat or mouse) resulting in less variable measurements
• Faster measurement, less traumatic for the tissues
• Digital measurement with metrological traceability
Furthermore, this pincher-based analgesia meter can also be used for other applications that require a controlled force or pressures values, for example :
• Sensitivity recovery after nerve crush: pinching is applied at several places over the paw to see the sensitivity recovery
• Mechanical injuries for thrombotic models
• Mechanical stimulation for in vivo electrophysiological recordings using the possibility to trigger recording on force thresholds
Comparative studies (including comparative tests with the Randall & Sellito analgesimeter) have demonstrated the accuracy of this pincher-based algometer for easy, fast and reproducible measurement of mechanical pain threshold on rat limbs. Moreover, it allowed to perform rat analagesia testing with minimal constraint, which reduces data variability.One of these experimental research works was carried out by the team of Prof. Poisbeau in the 'Nociception & Pain' department of the 'Institut des Neurosciences Cellulaires et Intégratives' (Université Louis pasteur) in Strasbourg.
This work was described in two articles published in December 2005 in international reviews with a controlling committee:
• Validation method :
Calibrated Forceps: A Sensitive and Reliable Tool for Pain and Analgesia Studies, by Luis-Delgado et al. in The Journal of pain, December 2005
• Scientific work :
Inflammatory Pain Upregulates Spinal Inhibition via Endogenous Neurosteroid Production, by P. Poisbeau et al. in The Journal of neuroscience, December 2005
Operating principle
The pressure is applied in the 'inter-digital' region. When used on the rat the pressure can also be applied to the tail. The instrument displays the force (in grams, newton, oz, lbs) at which the animal reacts and reports the nociception threshold.
Individual pain threshold measurements (up to 100) are stored in the internal memory, and can be downloaded post experiment. Recently an embedded statistical computation has been included in the electronic device of the algometer. This is a very useful feature that as been very well received and used by users of large numbers of tests. The display shows in real time the mean, standard deviation and variation coefficient from groups of animals (rats or mice). This feature also allows the user to cancel any analgesia test incorrectly performed.
NEW: Wireless
A full range of devices, including the Rodent Pincher now feature our new Wireless technology: thanks to the wireless transmitter on the operator’s wrist, there is no more cable between the electronic unit with the display and the sensors.
This new, wireless technology offers numerous advantages:
• Improved User range of motion : free from annoying cables !
• Flexible setup within the lab : Design your behavior room with fewer limitations
• Get rid of the physical constraints: Focus on your experiment only !
Options
• Our optional BIO-CIS2 software for Windows sends directly the displayed values in an Excel (MS) sheet. This allows the user direct access to a ready report and options for further analysis, without any re-copy error. Supplied with an RS232 cable.
• External pod to display a led light or produce a sound when reaching a preset threshold of force.
• Analog output and cable
• TTL output
• Additional sensor tests : our Electronic Von Frey probe, Small Animal Algometer come with their own calibration modules that are recognized by the electronic unit.Supplied with
• Bench control unit (batteries and main power supply)
• One rat or mice pincher, capacity 2000 grs
• Carrying case
• Footswitch for zeroing the force and having the hands 'free'
• RS232 output
• User manualNew system! AlgoKit
You may consider our new ALGOKIT package to expand the scope of your possibilities. In order to offer an answer to all your requests regarding different situations of pain measurement, Bioseb is proud to present an innovative, complete solution combining our Static Weight Bearing, including its state-of-the art touchscreen, color console, with up to 3 sensors to be chosen among our Electronic Von Frey, Rodent Pincher and Small animal Algometer, all connected to one unique Control Unit.
Features:
• Flexible instrument when a quantitative sensory testing (QST) is needed
• Compatible with our BIO-CIS2 software to improve repeatability in nociceptive testing
Data sheet
Number of publications:
A quick solution to determine the mechanical sensitivity threshold in rodents (mice and rats).
The latest evolution of Bioseb's Electronic Von Frey instrument for determining the mechanical sensitivity threshold in...
New ROBUST and modular cages to gently hold rodents (rats or mice) during nociceptive and analgesic tests including...
check_circle
check_circle