Aging Scientific Publications

Latest publication 07/10/2025

Age-dependent impairment of cardiac function and physical performance in male mi

Aging in the context of obesity exacerbates the risk of morbidity and mortality related to cardiovascular disease. However, the maladaptive...

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    [title] => Age-dependent impairment of cardiac function and physical performance in male mi
    [paragraph] => Age-dependent impairment of cardiac function and physical performance in male mice with diet-induced obesity
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Authors
Baumgarten, Patricia, Kamp, Justus, Hegemann, Niklas, Deubel, Stefanie, Berndt, Nikolaus, Grune, Jana, Kuebler, Wolfgang M., Axelrod, Christopher L., Kirwan, John P., Höhn, Annika, Heider, Sophie, Ott, Christiane, Grune, Tilman



 Lab


Journal
GeroScience


Abstract
Aging in the context of obesity exacerbates the risk of morbidity and mortality related to cardiovascular disease. However, the maladaptive responses in th


Keywords/Topics
Aging; Physical performance; Diet-induced obesity; Heart failure; Heart function
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.


New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)


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