Cognitive performance Scientific Publications

Latest publication 03/12/2024

Impact of enriched environment on motor performance and learning in mice

Neuroscience heavily relies on animal welfare in laboratory rodents as it can significantly affect brain development, cognitive function and memory...

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    [title] => Impact of enriched environment on motor performance and learning in mice
    [paragraph] => Impact of enriched environment on motor performance and learning in mice
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Authors
Dijkhuizen, S., Van Ginneken, L. M. C., IJpelaar, A. H. C., Koekkoek, S. K. E., De Zeeuw, C. I., Boele, H. J.

 Lab

Journal
Scientific Reports
Abstract
Neuroscience heavily relies on animal welfare in laboratory rodents as it can significantly affect brain development, cognitive function and memory formation. Unfortunately, laboratory animals are often raised in artificial environments devoid of physical and social stimuli, potentially leading to biased outcomes in behavioural assays. To assess this effect, we examined the impact of social and physical cage enrichment on various forms of motor coordination. Our findings indicate that while enriched-housed animals did not exhibit faster learning in eyeblink conditioning, the peak timing of their conditioned responses was slightly, but significantly, improved. Additionally, enriched-housed animals outperformed animals that were housed in standard conditions in the accelerating LE8305 and ErasmusLadder test. In contrast, we found no significant effect of enrichment on the balance beam and BIO-GS3. Overall, our data suggest that an enriched environment can improve motor performance and motor learning under challenging and/or novel circumstances, possibly reflecting an altered state of anxiety.
Keywords/Topics
Physical enrichment; Social enrichment; Cage enrichment; Delay eyeblink conditioning ;LE8305; Erasmus;Ladder ;Mice 
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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