General motor functions Scientific Publications

Latest publication 09/01/2025

Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis sy

Degeneration of both upper motor neurons in the brain and lower motor neurons in the spinal cord defines amyotrophic lateral sclerosis (ALS), but...

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    [title] => Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis sy
    [paragraph] => Cortical hyperexcitability drives dying forward amyotrophic lateral sclerosis symptoms and pathology in mice
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Authors
Mouna Haidar, Aida Viden, Christin Daniel, Brittany Cuic, Taide Wang, Marius Rosier, Doris Tomas, Samuel A. Mills, Alistair Govier-Cole, Elvan Djouma, Nirma D. Perera, Sophia Luikinga, Valeria Rytova, Samantha K. Barton, David G. Gonsalvez, Lucy M. Palmer, Catriona McLean, Matthew C. Kiernan, Steve Vucic, Bradley J. Turner

 Lab

Journal
Progress in Neurobiology
Abstract
Degeneration of both upper motor neurons in the brain and lower motor neurons in the spinal cord defines amyotrophic lateral sclerosis (ALS), but how …
Keywords/Topics
Amyotrophic lateral sclerosis;upper motor neurons;hyperexcitability;chemogenetics;mouse models
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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An easy way to objectively quantify the muscular strength of mice and rats, and to assess the effect of drugs, toxins, muscular (i.e. myopathy) and neurodegenerative diseases on muscular degeneration. It is widely used in conjunction with the ROTAROD motor coordination test: a normally coordinated rodent will show a decreased latency to fall off the rotating rod if its muscular strength is low. The Grip Strength Test is a must for your research on activity, motor control & coordination, and is particularly well suited for studies on Parkinson's & Huntington's disease.
New features GS4 - 2023: Color display with permanent backlight screen for easier reading, reset by footswitch, Improved battery time, Larger data memory of 500 values, Animal counter, USB port (charging/data transfer)

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