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Dernière publication 21/03/2019

Amelioration of muscle wasting by glucagon_like peptide_1 receptor agonist in mu

Skeletal muscle atrophy is deÞned as a reduction of muscle mass caused by excessive protein degradation. However, the development of therapeutic...

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    [title] => Amelioration of muscle wasting by glucagon_like peptide_1 receptor agonist in mu
    [paragraph] => Amelioration of muscle wasting by glucagon_like peptide_1 receptor agonist in muscle atrophy
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Authors
Y Hong, JH Lee, KW Jeong, CS Choi, HS Jun

 Lab
 College of Pharmacy, Gachon University, 7 45 Songdo-dong, Yeonsu-ku, Incheon, 406 840 , Korea
Journal
Journal of Cachexia, Sarcopenia and Muscle 
Abstract
 Skeletal muscle atrophy is deÞned as a reduction of muscle mass caused by excessive protein degradation. However, the development of therapeutic interventions is still in an early stage. Although glucagon-like peptide-1 receptor (GLP1R) agonists, such as exendin-4 (Ex-4) and dulaglutide, are widely used for the treatment of diabetes, their effects on muscle pathology are unknown. In this study, we investigated the therapeutic potential of GLP-1R agonist for muscle wasting and the mechanisms involved. 
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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