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Dernière publication 15/04/2020

Hypoglycaemic effect of catalpol in a mouse model of high-fat diet-induced pre-d

Type 2 diabetes mellitus is a major health problem and a societal burden. Individuals with pre-diabetes are at increased risk of type 2 diabetes...

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    [title] => Hypoglycaemic effect of catalpol in a mouse model of high-fat diet-induced pre-d
    [paragraph] => Hypoglycaemic effect of catalpol in a mouse model of high-fat diet-induced pre-diabetes
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Authors
D Xu, X Huang, HM Hassan, L Wang, S Li, Z Jiang

 Lab
China Pharmaceutical University, Jiangsu Key Laboratory of Drug Screening, Nanjing, China
Journal
Applied Physiology, Nutrition, and Metabolism
Abstract
Type 2 diabetes mellitus is a major health problem and a societal burden. Individuals with pre-diabetes are at increased risk of type 2 diabetes mellitus. Catalpol, an iridoid glycoside, has been reported to exert a hypoglycaemic effect in db/db mice, but its effect on the progression of pre-diabetes is unclear. In this study, we established a mouse model of pre-diabetes and examined the hypoglycaemic effect, and the mechanism of any such effect, of catalpol. Catalpol (200 mg/kg/day) had no effect on glucose tolerance or the serum lipid level in a mouse model of impaired glucose tolerance (IGT)-stage pre-diabetes. However, catalpol (200 mg/kg/day) increased insulin sensitivity and decreased the fasting glucose level in a mouse model of impaired fasting glucose/impaired glucose tolerance-stage pre-diabetes. Moreover, catalpol increased the mitochondrial membrane potential (1.52-fold) and ATP content (1.87-fold) in skeletal muscle and improved skeletal muscle function. These effects were mediated by activation of the IRS-1/GLUT4 signalling pathway in skeletal muscle. Our findings will facilitate the development of a novel approach to suppressing the progression of diabetes at an early stage.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Diabète, Insuline & Glucose; Métabolisme
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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