Neurodégénérescences générales - page 3 - Publications Scientifiques

Dernière publication 30/12/2019

Progressive age-dependent motor impairment in human tau P301S overexpressing mic

This study assessed the development of motor deficits in female hTau.P301S transgenic mice from 1.5 to 5.5 months of age. The test battery included...

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    [title] => Progressive age-dependent motor impairment in human tau P301S overexpressing mic
    [paragraph] => Progressive age-dependent motor impairment in human tau P301S overexpressing mice
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Authors
H Koivisto, E Ytebrouck, S Carmans, R Naderi et al

 Lab
A. I. Virtanen Institute, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Journal
Behavioural Brain Research
Abstract
This study assessed the development of motor deficits in female hTau.P301S transgenic mice from 1.5 to 5.5 months of age. The test battery included clasping reflex, grid hanging, Rotarod test, spontaneous explorative activity, Catwalk gait analysis, and nest building. Starting from the age of 2Ð3 months the mice showed marked hyperactivity, abnormal placing of weight on the hindlimbs and defective nest building in their home cage. These behavioral impairments did not progress with age. In addition, there was a progressive development of hindlimb clasping, inability to stay on a rotating rod or hang on a metal grid, and gait impairment. Depending on the measured output parameter, the motor impairment became significant from 3 to 4 months onwards and rapidly worsened until the age of 5.5 months with little inter-individual variation. The progressive motor impairment was paralleled by a robust increase in AT8 p-tau positive neurons in deep cerebellar nuclei and pontine brainstem between 3 and 5.5 months of age. The quick and steadily progressive motor impairment between 3 and 5.5 months of age accompanied by robust development of tau pathology in the hindbrain makes this mouse well suited for preclinical studies aiming at slowing down tau pathology associated with primary or secondary tauopathies.
BIOSEB Instruments Used
Aron Test or Four Plates Test (LE830),Rotarod (BX-ROD)

Keywords/Topics
Neurodégénérescences générales; Neurodégénérescence
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Un outil rapide pour l'évaluation de substances anxiolytiques putatives chez l'animal naïf. Un "must" pour l'étude de l'anxiété, le screening des drogues et le phénotypage.
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