Several lines of evidence indicate that the propagation of misfolded alpha_synuclein (alpha_syn) plays a central role in the progression and...
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[title] => Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and t
[paragraph] => Deficiency of the serine peptidase Kallikrein 6 does not affect the levels and the pathological accumulation of a_synuclein in mouse brain
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V Samantha Sykioti, M Karampetsou, I Chalatsa et al
Lab
Center for Basic Research, Biomedical Research Foundation Academy of Athens, Athens, Greece
Journal
Journal of Neurochemistry
Abstract
Several lines of evidence indicate that the propagation of misfolded alpha_synuclein (alpha_syn) plays a central role in the progression and manifestation of ParkinsonÕs disease. Pathogenic alpha_syn species can be present in the extracellular space. Thus, the identification and modulation of the key enzymes implicated in extracellular alpha_syn turnover becomes vital.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
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[description_short] => Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
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