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Dernière publication 17/02/2017

Application of calibrated forceps for assessing mechanical nociception with high

In order to investigate the basic physiological mechanisms of pain and the anti-nociceptive effects of analgesics, development of pain assays in...

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    [title] => Application of calibrated forceps for assessing mechanical nociception with high
    [paragraph] => Application of calibrated forceps for assessing mechanical nociception with high time resolution in mice
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Authors
Hideki Kashiwadani, Yuichi Kanmura, Tomoyuki Kuwaki

 Lab
Kagoshima University, Kagoshima, Japan
Journal
PLOS One
Abstract
In order to investigate the basic physiological mechanisms of pain and the anti-nociceptive effects of analgesics, development of pain assays in mice is critical due to the advances of genetic manipulation techniques. The von Frey hairs/Semmes-Weinstein monofilaments test (von Frey test) has long been applied to examine mechanical nociception in mice. Though the von Frey test is a well-established and standardized method, it is inappropriate to assess a rapid change in the nociceptive threshold because voluntary resting/sleeping states are necessary to examine the response. In this study, we assessed the effectiveness of calibrated forceps to determine the mechanical nociceptive threshold in mice. Repeated daily measurements of the threshold over 5 days indicated that the device obtained stable and reliable values. Furthermore, repeated measurements with 5 minute intervals revealed that the device detected the rapid change of the threshold induced by remifentanil, a shortacting_-receptor agonist. These results indicate that the calibrated forceps are well-suited for measuring the mechanical nociceptive threshold in mice, and are useful in assessing the effects of short-acting analgesics on mechanical nociception.
BIOSEB Instruments Used
Rodent pincher - analgesia meter (BIO-RP-M)
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Un algomètre rapide et précis, basé sur une pince instrumentée: une alternative au test de Randall-Selitto. Ce nouvel algésimètre développé par Bioseb selon Luis-Delgado et al. (2005) permet des tests nociceptifs précis et la mesure du seuil de douleur mécanique sur pattes de rats ou de souris, avec une contrainte minimale. Maintenant en version sans-fil, pour être libéré des câbles!

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