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Dernière publication 01/05/2016

Fondaparinux upregulates thrombomodulin and endothelial protein C receptor durin

Fondaparinux (FDX) was demonstrated to be cardioprotective in a rat model of myocardial ischemia reperfusion. In this model, FDX reduced infarct...

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    [title] => Fondaparinux upregulates thrombomodulin and endothelial protein C receptor durin
    [paragraph] => Fondaparinux upregulates thrombomodulin and endothelial protein C receptor during early-stage reperfusion in a rat model of myocardial infarction
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Authors
Guillou S, Tamareille S, Giraud S, Poitevin G, Prunier-Mirebeau D, Nguyen P, Prunier F, Macchi L



 Lab
CHU Poitiers, Service d'hématologie Biologique, Poitiers, France


Journal
Thromb Res.


Abstract
Fondaparinux (FDX) was demonstrated to be cardioprotective in a rat model of myocardial ischemia reperfusion. In this model, FDX reduced infarct size after 2h of reperfusion, involving the activation of the survivor activating factor enhancement (SAFE) pathway as early as 30min post-reperfusion. Our aim was to study if this cardioprotection could be explained by anti-inflammatory mechanisms and a protective effect on vessels.

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