Publications

Dernière publication 26/02/2016

Effects of glia metabolism inhibition on nociceptive behavioral testing in rats

Fluoroacetate has been widely used to inhibit glia metabolism in vivo. It has yet to be shown what the effects of chronic intrathecal infusion of...

Array
(
    [id_prestablog_news] => 834
    [id_shop] => 1
    [date] => 2016-02-26 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 1632
    [id_lang] => 2
    [title] => Effects of glia metabolism inhibition on nociceptive behavioral testing in rats
    [paragraph] => Effects of glia metabolism inhibition on nociceptive behavioral testing in rats
    [content] => 
Authors
Lefèvre Y, Amadio A, Vincent P, Descheemaeker A, Oliet SH, Dallel R, Voisin DL



 Lab
Neurocentre Magendie, Inserm U1215, F-33000 Bordeaux, France; Univ. Bordeaux, F-33000 Bordeaux, France.


Journal
Data Brief. 


Abstract
Fluoroacetate has been widely used to inhibit glia metabolism in vivo. It has yet to be shown what the effects of chronic intrathecal infusion of fluoroacetate on nociceptive behavioral testing are. The effects of chronic infusion of fluoroacetate (5 nmoles/h) for 2 weeks were examined in normal rats. Chronic intrathecal fluoroacetate did not alter mechanical threshold (von Frey filaments), responses to supra-threshold mechanical stimuli (von Frey filaments), responses to hot (hot plate) or cool (acetone test) stimuli and did not affect motor performance of the animals, which was tested with rotarod. This suggests that fluoroacetate at appropriate dose did not suppress neuronal activity in the spinal cord.
BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP)

    [meta_description] => 
    [meta_keywords] => http://www.ncbi.nlm.nih.gov/pubmed/26977440
    [meta_title] => 
    [link_rewrite] => effects-of-glia-metabolism-inhibition-on-nociceptive-behavioral-testing-in-rats
    [actif_langue] => 1
    [read] => 904
    [count_comments] => 0
    [id] => 834
    [categories] => Array
        (
            [26] => Array
                (
                    [id_prestablog_categorie] => 26
                    [title] => Domaines de recherche divers
                    [link_rewrite] => Domaines-de-recherche-divers
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Effects of glia metabolism inhibition on nociceptive behavioral testing in rats
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [563] => Array
                (
                    [name] => Plaque froid et chaud
                    [description_short] => 
Instrument de test de la sensibilité de l'animal à la douleur résultant de l'exposition à la chaleur ou au froid: la plaque froid et chaud de Bioseb est un instrument innovant ouvrant de nouveaux champs d'investigation pour vos recherches en analgésie et nociception, et un outil efficace pour le screening de substances analgésiques basé sur les modèles de rat ou souris.


Instrument for ratsInstrument for mice

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-thermique/563-cold-hot-plate-test.html
                )

        )

)
1
En lire plus

Filtres

Tout effacer

Categories

View all products

Applications

Dates

<< 1 ... 92 93 94 95 96 >>