Publications

Dernière publication 12/04/2014

Antiallodynic and antihyperalgesic activity of 3-[4--3-trifluoromethyl-phenyl--p

Background Anticancer drugs — oxaliplatin (OXPT) and paclitaxel (PACLI) cause painful peripheral neuropathy activating Transient Receptor...

Array
(
    [id_prestablog_news] => 590
    [id_shop] => 1
    [date] => 2014-04-12 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 1156
    [id_lang] => 2
    [title] => Antiallodynic and antihyperalgesic activity of 3-[4--3-trifluoromethyl-phenyl--p
    [paragraph] => Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice
    [content] => 
Authors
K. Salata, A. Ciosb, E. Wyskab, R. Salatc, S. Mogilski et al.

 Lab
Jagiellonian University, Cracow, Poland
Journal
Pharmacology Biochemistry and Behavior
Abstract
Background
Anticancer drugs — oxaliplatin (OXPT) and paclitaxel (PACLI) cause painful peripheral neuropathy activating Transient Receptor Potential (TRP) channels. Here we investigated the influence of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one (LPP1) and pregabalin on nociceptive thresholds in neuropathic pain models elicited by these drugs. Pharmacokinetics of LPP1 and its ability to attenuate neurogenic pain caused by TRP agonists: capsaicin and allyl isothiocyanate (AITC) were also investigated.
Methods
Antiallodynic and antihyperalgesic effects of intraperitoneally administered LPP1 and pregabalin were tested in the von Frey, hot plate and cold water tests. The influence of LPP1 on locomotor activity and motor coordination was assessed using actimeters and rotarod. Serum and tissue concentrations of LPP1 were measured using the HPLC method with fluorimetric detection.
Results
In OXPT-treated mice LPP1 and pregabalin dose-dependently reduced tactile allodynia (41–106% and 6–122%, respectively, p < 0.01). At the dose of 10 mg/kg LPP1 attenuated cold allodynia. In PACLI-treated mice LPP1 and pregabalin reduced tactile allodynia by 12–63% and 8–50%, respectively (p < 0.01). Both drugs did not affect cold allodynia, whereas pregabalin (30 mg/kg) attenuated heat hyperalgesia (80% vs. baseline latency time; p < 0.01). No motor impairments were observed in LPP1 or pregabalin-treated neuropathic mice in the rotarod test, while severe sedation was noted in the locomotor activity test. LPP1 reduced pain induced by capsaicin (51%; p < 0.01) and AITC (41%; p < 0.05). The mean serum concentration of LPP1 measured 30 min following i.p. administration was 7904.6 ± 1066.1 ng/ml. Similar levels were attained in muscles, whereas brain concentrations were 62% lower. Relatively high concentrations of LPP1 were also determined in the cerebrospinal fluid and the sciatic nerve.
Conclusions
LPP1 and pregabalin reduce pain in OXPT and PACLI-treated mice. This activity of LPP1 might be in part attributed to the inhibition of TRPV1 and TRPA1 channels, but also central mechanisms of action cannot be ruled out.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
    [meta_description] => 
    [meta_keywords] => http://www.sciencedirect.com/science/article/pii/S009130571400104X
    [meta_title] => 
    [link_rewrite] => antiallodynic-and-antihyperalgesic-activity-of-3-4--3-trifluoromethyl-phenyl--piperazin-1-yl-dihydrofuran-2-one-compared-to-pregabalin-in-chemotherapy-induced-neuropathic-pain-in-mice
    [actif_langue] => 1
    [read] => 157
    [count_comments] => 0
    [id] => 590
    [categories] => Array
        (
            [36] => Array
                (
                    [id_prestablog_categorie] => 36
                    [title] => Allodynie mécanique & Hyperalgésie
                    [link_rewrite] => Allodynie-mecanique-Hyperalgesie
                )

            [10] => Array
                (
                    [id_prestablog_categorie] => 10
                    [title] => Douleur
                    [link_rewrite] => Douleur
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Antiallodynic and antihyperalgesic activity of [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [1859] => Array
                (
                    [name] => Von Frey Électronique - Sans Fil
                    [description_short] => 
Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1859-electronic-von-frey-4.html
                )

            [1860] => Array
                (
                    [name] => Von Frey Électronique 5 avec caméra intégrée
                    [description_short] => 

En tant que version électronique du classique esthésiomètre à filaments de Von Frey, la dernière évolution de l’instrument électronique Von Frey de Bioseb, conçu pour déterminer le seuil de sensibilité mécanique chez les rongeurs (rats et souris) par stimulation sous la patte, est un outil indispensable pour vos recherches sur l’hyperalgésie et l’allodynie. En mesurant et en enregistrant la force à laquelle l’animal présente un réflexe de retrait de la patte, il est possible d’étudier les pathologies liées à la réponse sensorielle ainsi qu’à l’hyper- ou l’hypoesthésie.
L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/1860-electronic-von-frey-5-with-embedded-camera.html
                )

        )

)
1