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Dernière publication 01/04/2024

Bioengineered cell-constructs using decellularized fish skin-based composite bio

A biocomposite for enhancing muscle tissue regeneration was introduced using decellularized fish skins. Decellularized tilapia and cod skin were...

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    [title] => Bioengineered cell-constructs using decellularized fish skin-based composite bio
    [paragraph] => Bioengineered cell-constructs using decellularized fish skin-based composite bioink for regenerating muscle tissue
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Authors
SeoYul Jo; Hyeongjin Lee; Yunju Jo; Eun-Ju Jin; Dongyun Kim; Dongryeol Ryu; Geun Hyung Kim

 Lab
Sungkyunkwan University School of Medicine, Corea
Journal
Applied Physic Reviews
Abstract
A biocomposite for enhancing muscle tissue regeneration was introduced using decellularized fish skins. Decellularized tilapia and cod skin were explored as constituents of the composite and compared with the conventionally used decellularized extracellular matrix (dECM) derived from porcine skin tissue. As a cell-laden bioink for 3D bioprinting, the choice of tilapia skin dECM, which possesses remarkable printability, allows for precise three-dimensional (3D) structure fabrication. Meanwhile, cod skin dECM was selected as the dispersed phase for enhancing biological activities because of its omega-3 unsaturated fatty acid, which is known to promote angiogenesis and is crucial for nutrient supply during tissue regeneration and lower inflammation. Through meticulous compositional optimization of the fish skin dECMs, efficient printability and high myogenic activity of the fish skin dECM composite were attained. In vitro evaluations using adipose stem cells clearly demonstrated the support of the cell-laden composite bioink for myogenesis, as determined by various cellular activities, including myogenic genes, compared to those of the porcine-based dECM bioink. The regenerative potential of the composites was validated using an in vivo mouse model of volumetric muscle loss. Based on these results, this study provides valuable insights into the use of decellularized fish skin as composite biomaterials and demonstrates their distinct advantages in muscle tissue engineering, in terms of both printability and bioactivity induction.
BIOSEB Instruments Used
Grip strength test (BIO-GS4)
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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