Douleurs neuropathiques - page 6 - Publications Scientifiques

Dernière publication 02/12/2018

Amylin- a peptide expressed by nociceptors- modulates chronic neuropathic pain

Continuous subcutaneous amylin administration aggravated cold allodynia in SNI_animals, possibly via amylin_receptors (AmyR) in supraspinal areas....

Array
(
    [id_prestablog_news] => 1093
    [id_shop] => 1
    [date] => 2018-12-02 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 2148
    [id_lang] => 2
    [title] => Amylin- a peptide expressed by nociceptors- modulates chronic neuropathic pain
    [paragraph] => Amylin, a peptide expressed by nociceptors, modulates chronic neuropathic pain
    [content] => 
Authors
LS Almeida, JM Castro_Lopes, FL Neto, CS Potes

 Lab
Universidade do Porto, Alameda Prof Hernâni Monteiro, Porto, Portugal
Journal
European Journal of Pain
Abstract
Continuous subcutaneous amylin administration aggravated cold allodynia in SNI_animals, possibly via amylin_receptors (AmyR) in supraspinal areas. Acute intrathecal administration of amylin attenuated mechanical hyperalgesia, whereas AC187 reduced mechanical allodynia, suggesting distinct roles of endogenous amylin and of pharmacological amylin doses when targeting spinal cord amylin_receptors. Chronic amylin administration promoted c_Fos activation only in the dorsal horn neurons of SHAM_animals, suggesting a distinctive role of amylin in the activation of the spinal neuronal circuitry under neuropathic and physiological conditions. ERK1/2 phosphorylation increased in the dorsal horn neurons of SNI_rats chronically treated with amylin. This ERK1/2 cascade activation may be related with amylin's effect on the aggravation of cold allodynia in SNI_rats. Amylin's nociceptive effects seem to depend on the treatment duration and route of administration by acting at different levels of the nervous system.
BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP)

Keywords/Topics
Douleurs neuropathiques; Douleur
    [meta_description] => 
    [meta_keywords] => https://onlinelibrary.wiley.com/doi/abs/10.1002/ejp.1347
    [meta_title] => 
    [link_rewrite] => amylin--a-peptide-expressed-by-nociceptors--modulates-chronic-neuropathic-pain
    [actif_langue] => 1
    [read] => 1021
    [count_comments] => 0
    [id] => 1093
    [categories] => Array
        (
            [10] => Array
                (
                    [id_prestablog_categorie] => 10
                    [title] => Douleur
                    [link_rewrite] => Douleur
                )

            [29] => Array
                (
                    [id_prestablog_categorie] => 29
                    [title] => Douleurs neuropathiques
                    [link_rewrite] => Douleurs-neuropathiques
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Amylin, a peptide expressed by nociceptors, modulates chronic neuropathic pain
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [563] => Array
                (
                    [name] => Plaque froid et chaud
                    [description_short] => 
Instrument de test de la sensibilité de l'animal à la douleur résultant de l'exposition à la chaleur ou au froid: la plaque froid et chaud de Bioseb est un instrument innovant ouvrant de nouveaux champs d'investigation pour vos recherches en analgésie et nociception, et un outil efficace pour le screening de substances analgésiques basé sur les modèles de rat ou souris.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-thermique/563-cold-hot-plate-test.html
                )

        )

)
1