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Dernière publication 30/04/2012

The deletion of STOP and MAP6 protein in mice triggers highly altered mood and i

The microtubule-associated Stable Tubulie Only Polypeptide (STOP; also known as MAP6) protein plays a key role in neuron architecture and synaptic...

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    [title] => The deletion of STOP and MAP6 protein in mice triggers highly altered mood and i
    [paragraph] => The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. 
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Authors
V. Fournet, A. Schweitzer, C. Chevarin, J.-C. Deloulme, M. Hamon et al. 

 Lab
INSERM UMRS 952, CNRS UMR 7224, Université Pierre et Marie Curie, Paris, France.
Journal
Journal of Neurochemistry
Abstract
The microtubule-associated Stable Tubulie Only Polypeptide (STOP; also known as MAP6) protein plays a key role in neuron architecture and synaptic plasticity, the dysfunctions of which are thought to be implicated in the pathophysiology of psychiatric diseases. The deletion of STOP in mice leads to severe disorders reminiscent of several schizophrenia-like symptoms, which are also associated with differential alterations of the serotonergic tone in somas versus terminals. In STOP knockout (KO) compared with wild-type mice, serotonin (5-HT) markers are found to be markedly accumulated in the raphe nuclei and, in contrast, deeply depleted in all serotonergic projection areas. In the present study, we carefully examined whether the 5-HT imbalance would lead to behavioral consequences evocative of mood and/or cognitive disorders. We showed that STOP KO mice exhibited depression-like behavior, associated with a decreased anxiety-status in validated paradigms. In addition, although STOP KO mice had a preserved very short-term memory, they failed to perform well in all other learning and memory tasks. We also showed that STOP KO mice exhibited regional imbalance of the norepinephrine tone as observed for 5-HT. As a consequence, mutant mice were hypersensitive to acute antidepressants with different selectivity. Altogether, these data indicate that the deletion of STOP protein in mice caused deep alterations in mood and cognitive performances and that STOP protein might have a crucial role in the 5-HT and norepinephrine networks development.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5)

Keywords/Topics
Dépression; Troubles de l'humeur
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