Publications

Dernière publication 26/04/2021

Linalool odor_induced analgesia is triggered by TRPA1-independent pathway in mic

We had recently reported that linalool odor exposure induced significant analgesic effects in mice and that the effects were disappeared in...

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    [title] => Linalool odor_induced analgesia is triggered by TRPA1-independent pathway in mic
    [paragraph] => Linalool odor_induced analgesia is triggered by TRPA1-independent pathway in mice
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Authors
H Kashiwadani, Y Higa, M Sugimura et al

 Lab
Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan
Journal
Behavioral and Brain Functions
Abstract
We had recently reported that linalool odor exposure induced significant analgesic effects in mice and that the effects were disappeared in olfactory-deprived mice in which the olfactory epithelium was damaged, thus indicating that the effects were triggered by chemical senses evoked by linalool odor exposure. However, the peripheral neuronal mechanisms, including linalool receptors that contribute toward triggering the linalool odor-induced analgesia, still remain unexplored. In vitro studies have shown that the transient receptor potential ankyrin 1 (TRPA1) responded to linalool, thus raising the possibility that TRPA1 expressed on the trigeminal nerve terminal detects linalool odor inhaled into the nostril and triggers the analgesic effects. To address this hypothesis, we measured the behavioral pain threshold for noxious mechanical stimulation in TRPA1-defcient mice. In contrast to our expectation, we found a significant increase in the threshold after linalool odor exposure in TRPA1-defcient mice, indicating the analgesic effects of linalool odor even in TRPA1-defcient mice. Furthermore, intranasal application of TRPA1 selective antagonist did not alter the analgesic effect of linalool odor. These results showed that the linalool odor-induced analgesia was triggered by a TRPA1-independent pathway in mice.
BIOSEB Instruments Used
Rodent pincher - analgesia meter (BIO-RP-M)

Keywords/Topics
Système somatosensoriel
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Un algomètre rapide et précis, basé sur une pince instrumentée: une alternative au test de Randall-Selitto. Ce nouvel algésimètre développé par Bioseb selon Luis-Delgado et al. (2005) permet des tests nociceptifs précis et la mesure du seuil de douleur mécanique sur pattes de rats ou de souris, avec une contrainte minimale. Maintenant en version sans-fil, pour être libéré des câbles!

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