Système somatosensoriel - page 2 - Publications Scientifiques

Dernière publication 27/03/2018

CNS myeloid cells critically regulate heat hyperalgesia

Activation of non-neuronal microglia is thought to play a causal role in spinal processing of neuropathic pain. To specifically investigate...

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    [title] => CNS myeloid cells critically regulate heat hyperalgesia 
    [paragraph] => CNS myeloid cells critically regulate heat hyperalgesia 
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Authors
S Kalin, KR Miller, RE. Kalin, M Jendrach, C Witzel, FL Heppner

 Lab
Department of Neuropathology, Charite_platz, Berlin, Germany
Journal
The Journal of Clinical Investigation 
Abstract
Activation of non-neuronal microglia is thought to play a causal role in spinal processing of neuropathic pain. To specifically investigate microglia-mediated effects in a model of neuropathic pain and overcome the methodological limitationsof previous approaches exploring microglia function upon nerve injury, we selectively ablated resident microglia by intracerebroventricular ganciclovir infusion into male CD11b-HSVTK–transgenic mice, which was followed by a rapid, complete, and persistent (23 weeks) repopulation of the CNS by peripheral myeloid cells. In repopulated mice that underwent sciatic nerve injury, we observed a normal response to mechanical stimuli, but an absence of thermal hypersensitivity ipsilateralto the injured nerve. Furthermore, we found that neuronal expression of calcitonin gene–related peptide (CGRP), which isa marker of neurons essential for heat responses, was diminished in the dorsal horn of the spinal cord in repopulated mice. These findings identify distinct mechanisms for heat and mechanical hypersensitivity and highlight a crucial contribution of CNS myeloid cells in the facilitation of noxious heat.
BIOSEB Instruments Used
Von Frey Filaments (Bio-VF-M)

Keywords/Topics
Douleurs chroniques; Allodynie mécanique & Hyperalgésie; Moelle épinière; Perception du chaud et du froid; Système somatosensoriel; Système sensoriel; Système Nerveux Central (SNC); Douleur
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