Publications

Dernière publication 30/07/2008

Acetaminophen Reinforces Descending Inhibitory Pain Pathways-

The mechanism of the analgesic action of acetaminophen involves the serotonergic system. This study explores how acetaminophen interferes with...

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    [title] => Acetaminophen Reinforces Descending Inhibitory Pain Pathways-
    [paragraph] => Acetaminophen Reinforces Descending Inhibitory Pain Pathways.
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Authors
G. Pickering, V. Estève, M.-A. Loriot, A. Eschalier, C. Dubray.

 Lab
?
Journal
Clinical Pharmacology and Therapeutics
Abstract
The mechanism of the analgesic action of acetaminophen involves the serotonergic system. This study explores how acetaminophen interferes with serotonergic descending pain pathways. Eighteen rapid metabolizers of tropisetron were included in this double-blind cross-over study. After ethical approval, the healthy volunteers took 1 g oral acetaminophen (A) or placebo (p) combined with either the 5-HT3 antagonist tropisetron (T) (5 mg) or saline, intravenously, at weekly intervals. Mechanical pain thresholds, determined before and after a cold pressor test (CPT), were repeated seven times during the three post-dosing hours, and area under the concentration–time curves (AUCs) of the three treatments were compared. After CPT, AUC (%*min) of Ap (1,561±429) was larger than before CPT (393±382, P<0.05); these effects were totally inhibited by tropisetron. Acetaminophen reinforces descending inhibitory pain pathways; it suggests a supraspinal target for acetaminophen’s antinociceptive action. This study also confirmed that there is a central serotonergic mechanism of action for acetaminophen that is not stimulus-dependent.
BIOSEB Instruments Used
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)

Keywords/Topics
Accidents ischémiques transitoires (AIT); Pharmacologie; Système Nerveux Central (SNC); Thématiques transversales
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Une solution rapide pour déterminer le seuil de sensibilité à la douleur mécanique chez les rongeurs (rats et souris). Maintenant en version sans-fil, pour être libéré des câbles!

Cet instrument électronique précis et simple d'utilisation est le test de référence pour vos recherches en analgésie, nociception, neuropathies et douleurs post-opératoires

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L'EVF5 intègre une caméra embarquée au niveau de la zone de stimulation et fonctionne avec un nouveau logiciel dédié révolutionnaire

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