Publications

Dernière publication 09/04/2008

Anxiolytic-like effects of DOI microinjections into the hippocampus -but not the

Anxiolytic-like effects of DOI, a 5-HT2A/2C agonist have been observed in the four plates test (FPT) after intra-peritoneal administrations. In the...

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    [title] => Anxiolytic-like effects of DOI microinjections into the hippocampus -but not the
    [paragraph] => Anxiolytic-like effects of DOI microinjections into the hippocampus (but not the amygdala nor the PAG) in the mice four plates test.
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Authors
F. Masse, B. Petit-Demouliere, I. Dubois, M. Hascoët, M. Bourin.

 Lab
Faculté de Médecine, EA 3256 «Neurobiologie de l’anxiété et de la dépression », Nantes, France.
Journal
Behavioural Brain Research
Abstract
Anxiolytic-like effects of DOI, a 5-HT2A/2C agonist have been observed in the four plates test (FPT) after intra-peritoneal administrations. In the present study, DOI (1 _g, 2 _g or 5 _g per mice) was directly injected to three brain structures, the hippocampus, the amygdala and the periaqueductal gray matter (PAG). Tests were carried out immediately after injections. In amygdala and PAG, DOI exerted an anxiogenic-like effect. In the hippocampus, a strong anxiolytic-like effect was found only when injecting 5 _g DOI/mice in the FPT, with a size effect comparable to the anxiolytic-like effect of diazepam 1 mg/kg injected intra-peritoneally. DOI or vehicle injections did not affect locomotor activity. These results help us to understand mechanisms of action of DOI in animal models of anxiety, probably through an interaction with other neurotransmitter system, which may take place in the hippocampus.
BIOSEB Instruments Used
Aron Test or Four Plates Test (LE830)

Keywords/Topics
Domaines de recherche divers
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Un outil rapide pour l'évaluation de substances anxiolytiques putatives chez l'animal naïf. Un "must" pour l'étude de l'anxiété, le screening des drogues et le phénotypage.
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