Publications

Dernière publication 21/02/2011

GABAergic pathway in a rat model of chronic neuropathic pain- Modulation after i

Current understanding of chronic pain points a decrease in level of the inhibitory neurotransmitter GABA, in the spinal dorsal horn, leading to an...

Array
(
    [id_prestablog_news] => 302
    [id_shop] => 1
    [date] => 2011-02-21 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 602
    [id_lang] => 2
    [title] => GABAergic pathway in a rat model of chronic neuropathic pain- Modulation after i
    [paragraph] => GABAergic pathway in a rat model of chronic neuropathic pain: Modulation after intrathecal transplantation of a human neuronal cell line. 
    [content] => 
Authors
L. Vaysse, J.C. Sol, Y. Lazorthes, M. Courtade-Saidi, M.J. Eaton et al. 

 Lab
Laboratory of Approches expérimentales et Thérapeutiques des Douleurs Neuropathiques, Toulouse, France.
Journal
Neuroscience Research
Abstract
Current understanding of chronic pain points a decrease in level of the inhibitory neurotransmitter GABA, in the spinal dorsal horn, leading to an imbalance between excitatory and inhibitory pathways. A subcloned derivative of the human NT2 cell line (hNT2.17) which, after neuronal differentiation, secretes different inhibitory neurotransmitters such as GABA and glycine has been recently isolated. In this study, we have investigated the effect of this new cell line on peripheral nerve injury induced by chronic constriction (CCI) and notably the effect on the cellular GABAergic pathway. Our data show that the decrease in GABA expression in the spinal dorsal horn of injured animals is concomitant with a decline of its synthetic enzyme GAD67-Ir and mRNA but not GAD65. Interestingly, in transplanted animals we observed a strong induction of GAD67 mRNA with one week after graft, which is followed by a recovery of GAD67 and GABA Ir. This effect paralleled a reduction of hindpaw hypersensitivity and thermal hyperalgesia induced by CCI. These results suggest that hNT2.17 GABA cells can modulate neuropathic pain after CCI certainly by minimizing the imbalance and restoring the cellular GABAergic pathway.
BIOSEB Instruments Used
Static Weight Bearing Touch: Incapacitance Test (BIO-SWB-TOUCH-M)

Keywords/Topics
Douleurs neuropathiques; Douleurs chroniques; Douleur
    [meta_description] => 
    [meta_keywords] => http://www.sciencedirect.com/science/article/pii/S016801021002818X
    [meta_title] => 
    [link_rewrite] => gabaergic-pathway-in-a-rat-model-of-chronic-neuropathic-pain--modulation-after-intrathecal-transplantation-of-a-human-neuronal-cell-line--
    [actif_langue] => 1
    [read] => 1071
    [count_comments] => 0
    [id] => 302
    [categories] => Array
        (
            [10] => Array
                (
                    [id_prestablog_categorie] => 10
                    [title] => Douleur
                    [link_rewrite] => Douleur
                )

            [30] => Array
                (
                    [id_prestablog_categorie] => 30
                    [title] => Douleurs chroniques
                    [link_rewrite] => Douleurs-chroniques
                )

            [29] => Array
                (
                    [id_prestablog_categorie] => 29
                    [title] => Douleurs neuropathiques
                    [link_rewrite] => Douleurs-neuropathiques
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => GABAergic pathway in a rat model of chronic neuropathic pain: Modulation after intrathecal [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [27] => Array
                (
                    [name] => Distribution pondérale statique : Test d'incapacitance (SWB-Touch)
                    [description_short] => 
Test non douloureux pour mesurer le niveau d'inconfort (incapacitance) de petits animaux comme les rats et les souris via leur équilibre postural - indépendamment de l'opérateur. Le test de distribution pondérale statique est l'instrument idéal pour vos recherches en nociception et analgésie impliquant des rongeurs: arthrose, dégénération du cartilage, modèles d'inflammation, modèles de traumatismes nerveux , et bien plus... Notre nouveau SWB-Touch inclue désormais un tout nouvel écran tactile!

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-spontanee-deficit-de-posture/27-static-weight-bearing-touch-incapacitance-test.html
                )

        )

)
1