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Dernière publication 01/02/2024

Dietary marine hydrolysate alleviates D-galactose-induced brain aging by attenua

Aging represents a natural and unavoidable phenomenon in organisms. With the acceleration of population aging, investigations into aging have...

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    [title] => Dietary marine hydrolysate alleviates D-galactose-induced brain aging by attenua
    [paragraph] => Dietary marine hydrolysate alleviates D-galactose-induced brain aging by attenuating cognitive alterations- oxidative stress and inflammation through the AGE-RAGE axis
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Authors
Camille Mougin, Mathilde Chataigner, Céline Lucas, Véronique Pallet, Elodie Bouvret, Corinne Joffre, Anne-Laure Dinel

 Lab

Journal
PLOS ONE
Abstract
Aging represents a natural and unavoidable phenomenon in organisms. With the acceleration of population aging, investigations into aging have garnered widespread global interest. One of the most striking aspects of human aging is the decline in brain function, a phenomenon intricately tied to the onset of neurodegenerative conditions. This study aimed to assess the impact of a fish hydrolysate, rich in low-molecular-weight peptides and n-3 LC-PUFAs, on cognitive function, inflammatory response, and oxidative stress via the AGE-RAGE axis in a mouse model of accelerated aging. This model induces cognitive decline and biochemical alterations akin to those observed during natural aging. The findings revealed that fish hydrolysate exhibited a protective effect against cognitive impairment induced by D-galactose. This effect was associated with increased protein expression of SOD1 and decreased genetic expression of IL-6 and advanced glycation end products (AGE). Consequently, within the realm of preventive and personalized nutrition, fish hydrolysate emerges as a promising avenue for mitigating age-related declines in memory function.
Keywords/Topics
dietary;marine;hydrolysate;alleviates;d-galactose-induced;brain;aging;attenuating;cognitive;alterations
BIOSEB Instruments Used:
Grip strength test (BIO-GS4),Rodent pincher - Analgesia meter - Wireless (BIO-RP-WRS)
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Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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