Publications

Dernière publication 04/05/2023

Muscle Injuries Induce a Prostacyclin-PPARγ and PGC1a-FAO Spike That Boosts Rege

It is well-known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise and...

Array
(
    [id_prestablog_news] => 1875
    [id_shop] => 1
    [date] => 2023-05-04 00:00:00
    [date_modification] => 2024-02-09 14:15:13
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 3417
    [id_lang] => 2
    [title] => Muscle Injuries Induce a Prostacyclin-PPARγ and PGC1a-FAO Spike That Boosts Rege
    [paragraph] => Muscle Injuries Induce a Prostacyclin-PPARγ and PGC1a-FAO Spike That Boosts Regeneration
    [content] => 
Authors
Luo L, Chua YB, Liu T, Liang K, Chua MJ, Ma W, Goh JW, Wang Y, Su J, Ho YS, Li CW, Liu KH, Teh BT, Yu K, Shyh-Chang N

 Lab
University of Chinese Academy of Sciences, Beijing, P. R. China
Journal
Adv Sci (Weinh)
Abstract
It is well-known that muscle regeneration declines with aging, and aged muscles undergo degenerative atrophy or sarcopenia. While exercise and acute injury are both known to induce muscle regeneration, the molecular signals that help trigger muscle regeneration have remained unclear. Here, mass spectrometry imaging (MSI) is used to show that injured muscles induce a specific subset of prostanoids during regeneration, including PGG1, PGD2, and the prostacyclin PGI2. The spike in prostacyclin promotes skeletal muscle regeneration via myoblasts, and declines with aging. Mechanistically, the prostacyclin spike promotes a spike in PPARγ/PGC1a signaling, which induces a spike in fatty acid oxidation (FAO) to control myogenesis. LC-MS/MS and MSI further confirm that an early FAO spike is associated with normal regeneration, but muscle FAO became dysregulated during aging. Functional experiments demonstrate that the prostacyclin-PPARγ/PGC1a-FAO spike is necessary and sufficient to promote both young and aged muscle regeneration, and that prostacyclin can synergize with PPARγ/PGC1a-FAO signaling to restore aged muscles' regeneration and physical function. Given that the post-injury prostacyclin-PPARγ-FAO spike can be modulated pharmacologically and via post-exercise nutrition, this work has implications for how prostacyclin-PPARγ-FAO might be fine-tuned to promote regeneration and treat muscle diseases of aging.
BIOSEB Instruments Used
Grip strength test (BIO-GS4)

Keywords/Topics
Système musculaire général
    [meta_description] => 
    [meta_keywords] => https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202301519
    [meta_title] => 
    [link_rewrite] => muscle-injuries-induce-a-prostacyclin-ppar-and-pgc1a-fao-spike-that-boosts-regeneration
    [actif_langue] => 1
    [read] => 754
    [count_comments] => 0
    [id] => 1875
    [categories] => Array
        (
            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [63] => Array
                (
                    [id_prestablog_categorie] => 63
                    [title] => Système musculaire général
                    [link_rewrite] => Systeme-musculaire-general
                )

        )

    [authors] => 
    [paragraph_crop] => Muscle Injuries Induce a Prostacyclin-PPARγ and PGC1a-FAO Spike That Boosts Regeneration
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

        )

)
1