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Dernière publication 01/02/2025

Sex-Specific Contrasting Role of BECLIN-1 Protein in Pain Hypersensitivity and A

Chronic pain is a debilitative disease affecting one in five adults globally and is a major risk factor for anxiety Goldberg and McGee, 2011;...

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    [title] => Sex-Specific Contrasting Role of BECLIN-1 Protein in Pain Hypersensitivity and A
    [paragraph] => Sex-Specific Contrasting Role of BECLIN-1 Protein in Pain Hypersensitivity and Anxiety-Like Behaviors
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Authors
Fariya Zaheer, Gabriel J. Levine, Ana Leticia Simal, Seyed Reza Fatemi Tabatabaei, Tami A. Martino, Giannina Descalzi

 Lab

Journal
eNeuro
Abstract
Chronic pain is a debilitative disease affecting one in five adults globally and is a major risk factor for anxiety Goldberg and McGee, 2011; Lurie, 2018). Given the current dearth of available treatments for both individuals living with chronic pain and mental illnesses, there is a critical need for research into the molecular mechanisms involved in order to discover novel treatment targets. Cellular homeostasis is crucial for normal bodily functions, and investigations of this process may provide better understanding of the mechanisms driving the development of chronic pain. Using the spared nerve injury (SNI) model of neuropathic pain, we found contrasting roles for BECLIN-1 in the development of pain hypersensitivity and anxiety-like behaviors in a sex-dependent manner. Remarkably, we found that male SNI mice with impaired BECLIN-1 function demonstrated heightened mechanical and thermal hypersensitivity compared with male wild-type SNI mice, while female SNI mice with impaired BECLIN-1 function demonstrated similar thresholds to the female wild-type SNI mice. We also found that disruptions of BECLIN-1 prevented SNI-induced increases in anxiety-like behaviors in male mice. Our data thus indicate that BECLIN-1 is differentially involved in the nociceptive and emotional components of chronic pain in male but not female mice.

Keywords/Topics
anxiety; autophagy; BECLIN-1; female; neuropathic pain; sex differences
BIOSEB Instruments Used:
Cold Hot Plate Test (BIO-CHP)
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