Publications

Dernière publication 14/07/2014

Antinociceptive activity of the new triple reuptake inhibitor NS18283 in a mouse

BACKGROUND: Chronic neuropathic pain can lead to anxiety and depression. Drugs that block reuptake of serotonin, norepinephrine and/or dopamine...

Array
(
    [id_prestablog_news] => 635
    [id_shop] => 1
    [date] => 2014-07-14 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 1242
    [id_lang] => 2
    [title] => Antinociceptive activity of the new triple reuptake inhibitor NS18283 in a mouse
    [paragraph] => Antinociceptive activity of the new triple reuptake inhibitor NS18283 in a mouse model of chemotherapy-induced neuropathic pain
    [content] => 
Authors
Hache G, Guiard BP, Nguyen TH, Quesseveur G, Gardier AM, Peters D, Munro G, Coudoré F.

 Lab
Paris Sud University, Châtenay-Malabry, France
Journal
Eur J Pain
Abstract
BACKGROUND:
Chronic neuropathic pain can lead to anxiety and depression. Drugs that block reuptake of serotonin, norepinephrine and/or dopamine are widely used to treat depression, and have emerged as useful drugs in the treatment of neuropathic pain. This study compared the acute antinociceptive effects of NS18283, a novel triple monoamine reuptake inhibitor (MRI) with indatraline, venlafaxine and escitalopram in a mouse model of neuropathic pain.

METHOD:
Neuropathic pain-like behaviours were induced in mice by repeated injections of oxaliplatin (OXA), and assessed using the von Frey hair test, the cold plate test and the thermal preference plate test. Anxio/depressive phenotype and antidepressant-like properties of compounds were assessed by the novelty suppressed feeding test and the tail suspension test, respectively.

RESULTS:
In vivo microdialysis experiments showed that each MRI increased extracellular serotonin, norepinephrine and/or dopamine levels in the cingulate cortex, in agreement with their in vitro reuptake inhibitory properties. Indatraline (3?mg/kg) reversed the full repertoire of OXA-induced neuropathic hypersensitivity. NS18283 (10?mg/kg) reversed OXA-induced mechano-hypersensitivity and cold allodynia. Venlafaxine (16?mg/kg) and escitalopram (4?mg/kg) only reversed cold allodynia and mechano-hypersensitivity, respectively. All MRIs produced antidepressant-like activity in anxio/depressive phenotype of OXA mice.

CONCLUSIONS:
Acute administration of drugs that enhance the activity of serotonin, norepinephrine and dopamine neurotransmission within nociceptive pathways may provide a broader spectrum of antinociception than dual or selective reuptake inhibitors in animal models of neuropathic pain. Whether similar observations would occur after repeated administration of such compounds in an attempt to simulate dosing in humans, or be compromised by dopaminergic-mediated adverse effects warrants further investigation.
BIOSEB Instruments Used
Von Frey Filaments (Bio-VF-M),Thermal Place Preference, 2 Temperatures Choice Nociception Test (BIO-T2CT)
    [meta_description] => 
    [meta_keywords] => http://www.ncbi.nlm.nih.gov/pubmed/25045036
    [meta_title] => 
    [link_rewrite] => antinociceptive-activity-of-the-new-triple-reuptake-inhibitor-ns18283-in-a-mouse-model-of-chemotherapy-induced-neuropathic-pain
    [actif_langue] => 1
    [read] => 1021
    [count_comments] => 0
    [id] => 635
    [categories] => Array
        (
            [26] => Array
                (
                    [id_prestablog_categorie] => 26
                    [title] => Domaines de recherche divers
                    [link_rewrite] => Domaines-de-recherche-divers
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Antinociceptive activity of the new triple reuptake inhibitor NS18283 in a mouse model of [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [577] => Array
                (
                    [name] => Filaments de Von Frey
                    [description_short] => 
Jeu de 20 filaments basé sur le jeu de monofilaments de Wemmes Weinstein - filament rétractable pour protéger celui-ci et faciliter le transport

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-mecanique/577-von-frey-filaments.html
                )

            [897] => Array
                (
                    [name] => Préférence de Place Thermique : Test de Choix entre 2 Températures
                    [description_short] => 
Un test indépendant de l'opérateur pour étudier les seuils de douleur chez les rongeurs (rats et souris) par l'évaluation de la préférence de température (zone de confort thermal) - un outil innovant pour vos recherches sur l'analgésie et la nociception, ouvrant de nouveaux champs d'étude, et une solution idéale pour le screening de médicaments analgésiques et nociceptifs. Désormais fourni avec un nouveau logiciel dernier cri permettant de monitorer l'activité et les transitions de température rapides!

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-thermique/897-thermal-place-preference-2-temperatures-choice-nociception-test.html
                )

        )

)
1