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Dernière publication 21/06/2014

Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidatio

Prospective studies reported an inverse correlation between 25 hydroxy-vitamin D plasma levels and prevalence of obesity and type 2 diabetes. In...

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    [title] => Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidatio
    [paragraph] => Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation ☆: Vitamin D protects against obesity onset
    [content] => 
Authors
J. Marcotorchino, F. Tourniairea, J. Astiera, E. Karkenia, M. Canaulta et al.

 Lab
Aix-Marseille Université, Marseille, France
Journal
The Journal of Nutritional Biochemistry
Abstract
Prospective studies reported an inverse correlation between 25 hydroxy-vitamin D plasma levels and prevalence of obesity and type 2 diabetes. In addition, 25 hydroxy-vitamin D status may be a determinant of obesity onset. However, the causality between these observations is not yet established. We studied the preventive effect of vitamin D3 supplementation (15000 IU/kg of food for 10 weeks) on onset of obesity in a diet-induced obesity mouse model. We showed that the vitamin D3 supplementation limited weight gain induced by high-fat diet, which paralleled with an improvement of glucose homeostasis. The limitation of weight gain could further be explained by an increased of lipid oxidation, possibly due to an up-regulation of genes involved in fatty acid oxidation and mitochondrial metabolism, leading to increased energy expenditure. Altogether, these data show that vitamin D3 regulates energy expenditure, and suggest that vitamin D3 supplementation may represent a strategy of preventive nutrition to fight the onset of obesity and associated metabolic disorders.
BIOSEB Instruments Used
OXYLET, Indirect Calorimeter (OXYLET)

Keywords/Topics
Obésité & Surpoids; Métabolisme
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