Publications

Dernière publication 03/02/2024

Identification of Peucedanum japonicum Thunb- extract components and their prote

Background: Peucedanum japonicum Thunb. (PJ) is a vegetable widely consumed in East Asia and is known to have anticancer and anti-inflammatory...

Array
(
    [id_prestablog_news] => 1935
    [id_shop] => 1
    [date] => 2024-02-03 00:00:00
    [date_modification] => 2024-05-10 10:07:34
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 3567
    [id_lang] => 2
    [title] => Identification of Peucedanum japonicum Thunb- extract components and their prote
    [paragraph] => Identification of Peucedanum japonicum Thunb- extract components and their protective effects against dexamethasone-induced muscle atrophy
    [content] => 
Authors
Kim YI, Lee H, Kim MJ, Jung CH, Kim YS, Ahn J.

 Lab
Korea National University of Science and Technology, Daejeon, South Korea
Journal
Phytomedicine.
Abstract
Background: Peucedanum japonicum Thunb. (PJ) is a vegetable widely consumed in East Asia and is known to have anticancer and anti-inflammatory effects. However, the effect of PJ on muscle atrophy remains elusive. Purpose: This study aimed to investigate the effect of PJ and its active compound on dexamethasone (DEX)-induced muscle atrophy. Methods: We performed qualitative and quantitative analysis of PJ using ultra-performance liquid chromatography-mass spectrometry tandem mass spectrometry (UPLC-MS/MS) and high-performance liquid chromatography (HPLC), respectively. The efficacy of PJ and its main compound 4-caffeoylquinic acid (CQA) on muscle atrophy was evaluated in DEX-induced myotube atrophy and DEX-induced muscle atrophy in mouse myoblasts (C2C12) and C57BL/6 mice, in vitro and in vivo, respectively. Results: The UPLC-MS/MS and HPLC data showed that the concentration of 4-CQA in PJ was 18.845 mg/g. PJ and 4-CQA treatments significantly inhibited DEX-induced myotube atrophy by decreasing protein synthesis and glucocorticoid translocation to the nucleus in C2C12 myotubes. In addition, PJ enhanced myogenesis by upregulating myogenin and myogenic differentiation 1 in C2C12 cells. PJ supplementation effectively increased muscle function and mass, downregulated atrogenes, and decreased proteasome activity in C57BL/6 mice. Additionally, PJ effectively decreased the nuclear translocation of forkhead transcription factor 3 alpha by inhibiting glucocorticoid receptor. Conclusion: Overall, PJ and its active compound 4-CQA alleviated skeletal muscle atrophy by inhibiting protein degradation. Hence, our findings present PJ as a potential novel pharmaceutical candidate for the treatment of muscle atrophy.
BIOSEB Instruments Used
Grip strength test (BIO-GS4)
    [meta_description] => 
    [meta_keywords] => https://www.sciencedirect.com/science/article/pii/S0944711324001144
    [meta_title] => 
    [link_rewrite] => identification-of-peucedanum-japonicum-thunb--extract-components-and-their-protective-effects-against-dexamethasone-induced-muscle-atrophy
    [actif_langue] => 1
    [read] => 332
    [count_comments] => 0
    [id] => 1935
    [categories] => Array
        (
            [65] => Array
                (
                    [id_prestablog_categorie] => 65
                    [title] => Atrophie musculaire
                    [link_rewrite] => Atrophie-musculaire
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Identification of Peucedanum japonicum Thunb- extract components and their protective effects [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

        )

)
1