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Dernière publication 01/03/2026

Polymeric nanoparticle-mediated GBA1 gene therapy is neuroprotective in a precli

Parkinson’s disease (PD) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia

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    [title] => Polymeric nanoparticle-mediated GBA1 gene therapy is neuroprotective in a precli
    [paragraph] => Polymeric nanoparticle-mediated GBA1 gene therapy is neuroprotective in a preclinical model of Parkinson’s disease
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Authors
Kwatra, Mohit, Kwak, Gijung, Li, Haolin, Suk, Jung Soo, Ko, Han Seok



 Lab


Journal
Drug Delivery and Translational Research


Abstract
Parkinson’s disease (PD) is a debilitating neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia


Keywords/Topics
Glucocerebrosidase 1; GCase; Αlpha-synuclein; Intracranial gene therapy; Convection-enhanced delivery; Polymeric nanoparticle; Neuroprotection; Neuroinflammation
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.


Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)


Instrument for ratsInstrument for mice

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