Publications

Dernière publication 20/12/2018

Inula Japonica Thunb- Flower Ethanol Extract Improves Obesity and Exercise Endur

Inula japonica Thunb. (Asteraceae) is a _owering plant that grows mainly in Korea, Japan, and China and its _ower extract has diverse biological...

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    [title] => Inula Japonica Thunb- Flower Ethanol Extract Improves Obesity and Exercise Endur
    [paragraph] => Inula Japonica Thunb. Flower Ethanol Extract Improves Obesity and Exercise Endurance in Mice Fed A High-Fat Diet
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Authors
SH Park, DH Lee, MJ Kim, J Ahn, YJ Jang, TY Ha

 Lab
Department of Food Biotechnology, Korea University of Science and Technology, Wanju-gun, Jeollabuk-do 55365, Korea
Journal
Nutrients
Abstract
 Inula japonica Thunb. (Asteraceae) is a _owering plant that grows mainly in Korea, Japan, and China and its _ower extract has diverse biological effects such as anti-in_ammatory and antioxidative activities. However, the effects on obesity and enhancement of endurance capacity have not been explored yet. This study aims to reveal the effects of I. japonica _ower ethanol extract (IJE)onobesityandendurancecapacityinhigh-fatdiet(HFD)fedC57BL/6Jmiceandthemechanism. IJE inhibited lipid accumulation in 3T3-L1 adipocytes in vitro. Also, IJE-fed mice showed reduced body weight gain, hepatic lipid, and body fat mass, and increased muscle weight. IJE reduced lipid accumulation in the liver and adipose tissue by decreasing lipogenic and adipogenic gene expression. Additionally,consumptionoflow-doseIJEsigni_cantlyenhancedendurancecapacityvia increasing AMP-activated protein kinase activity and mRNA levels of Myh7 and Myh2. Luteolin and 1_-hydroxyalantolactone (1_-HA), compounds of IJE, are involved in anti-adipogenesis in the 3T3-L cells and only luteolin increased the protein levels of MHC during C2C12 myoblast differentiation. Collectively, our results suggest that consumption of IJE not only helps to prevent obesity but also enhances endurance capacity reduced by HFD.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Obésité & Surpoids; Dépenses énergétiques; Métabolisme
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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