Douleurs neuropathiques - page 3 - Publications Scientifiques

Dernière publication 13/03/2026

A corticothalamic circuit modulates pain sensitivity and mediates innate fear-in

Fear and pain are two frequently co-occurring states that mammals need to orchestrate to ensure survival. Nevertheless, how the brain dynamically...

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    [title] => A corticothalamic circuit modulates pain sensitivity and mediates innate fear-in
    [paragraph] => A corticothalamic circuit modulates pain sensitivity and mediates innate fear-induced analgesia in male mice
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Authors
Jia, Wen-Bin, Wang, Xin-Yue, Xia, Xin-Xin, Tang, Liu, Liang, Yu-Xuan, Lei, Xiao-Lin, Liu, Xiao-Qing, Hu, Wei, Zhang, Yan

 Lab
Authors and Affiliations
Journal
Nature Communications
Abstract
Fear and pain are two frequently co-occurring states that mammals need to orchestrate to ensure survival. Nevertheless, how the brain dynamically prioritizes between them remains poorly understood. Here, we demonstrate that innate fear suppresses both acute and chronic pain, whereas pain does not reciprocally modulate fear responses in male mice. Using fiber photometry, virus tracing, and electrophysiological approaches, we show that exposure to a fear-inducing odor activates GABAergic neurons in the anterior piriform cortex (APC), which subsequently attenuates pain-associated hyperactivity in the downstream mediodorsal thalamus (MD). Crucially, inhibiting either APCGABA neurons or the APCGABA-MD circuit enhances pain sensitivity and abolishes fear-induced analgesia. Conversely, activation of APCGABA neurons or the APCGABA-MD circuit induces freezing responses and relieves pain, mimicking fear-induced analgesia. These findings unveil a corticothalamic circuit that bidirectionally regulates pain processing and underlies fear-provoked analgesia, offering potential therapeutic avenues for pain management. Survival requires prioritizing threats over pain. The authors identify a brain circuit in male mice, where fear signals from the cortex block pain-associated activation in the thalamus, revealing how fear suppresses pain and offering a potential target for therapies.
Keywords/Topics
Chronic pain; Neural circuits
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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