Publications

Dernière publication 14/01/2009

Isobolographic analysis of interactions between 1-methyl-1-2-3-4-tetrahydroisoqu

The anticonvulsant activity of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MeTHIQ — an endogenous parkinsonism-preventing substance) administered...

Array
(
    [id_prestablog_news] => 203
    [id_shop] => 1
    [date] => 2009-01-14 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 404
    [id_lang] => 2
    [title] => Isobolographic analysis of interactions between 1-methyl-1-2-3-4-tetrahydroisoqu
    [paragraph] => Isobolographic analysis of interactions between 1-methyl-1,2,3,4-tetrahydroisoquinoline and four conventional antiepileptic drugs in the mouse maximal. electroshock-induced seizure model
    [content] => 
Authors
J.J. Luszczki, L. Antkiewicz-Michaluk, S.J. Czuczwar.

 Lab
Medical University, Department of Pathophysiology, and Institute of Agricultural Medicine, Department of Physiopathology, Lublin, Poland.
Journal
European Journal of Pharmacology
Abstract
The anticonvulsant activity of 1-methyl-1,2,3,4-tetrahydroisoquinoline (MeTHIQ — an endogenous parkinsonism-preventing substance) administered alone and in combination with four conventional antiepileptic drugs (carbamazepine, phenytoin, phenobarbital and valproate) was determined in the mouse maximal electroshock-induced seizure model. The types of interactions of MeTHIQ with the antiepileptic drugs were characterized using isobolographic analysis. The isobolographic analysis revealed that the combination of MeTHIQ with phenobarbital at the fixed-ratios of 1:3, 1:1 and 3:1 exerted supra-additive (synergistic) interaction in the maximal electroshock-induced seizure test. In contrast, the combinations of MeTHIQ with carbamazepine, phenytoin and valproate exerted additive interaction for all three fixed-ratios (1:3, 1:1 and 3:1) tested in the maximal electroshock-induced seizure test. In conclusion, MeTHIQ produces a clear-cut anticonvulsant effect in the maximal electroshock-induced seizure test in mice. The supra-additive interaction of MeTHIQ with phenobarbital against maximal electroshock-induced seizures makes their combination of pivotal importance from a clinical viewpoint.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Épilepsie; Système Nerveux Central (SNC)
    [meta_description] => 
    [meta_keywords] => http://www.sciencedirect.com/science/article/pii/S0014299908012132
    [meta_title] => 
    [link_rewrite] => isobolographic-analysis-of-interactions-between-1-methyl-1-2-3-4-tetrahydroisoquinoline-and-four-conventional-antiepileptic-drugs-in-the-mouse-maximal--electroshock-induced-seizure-model
    [actif_langue] => 1
    [read] => 970
    [count_comments] => 0
    [id] => 203
    [categories] => Array
        (
            [41] => Array
                (
                    [id_prestablog_categorie] => 41
                    [title] => Épilepsie
                    [link_rewrite] => Épilepsie
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [11] => Array
                (
                    [id_prestablog_categorie] => 11
                    [title] => Système Nerveux Central (SNC)
                    [link_rewrite] => Systeme-Nerveux-Central-SNC
                )

        )

    [authors] => 
    [paragraph_crop] => Isobolographic analysis of interactions between 1-methyl-1,2,3,4-tetrahydroisoquinoline and [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

        )

)
1