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Dernière publication 01/11/2025

Relationship between simvastatin pharmacokinetics and muscle toxicity in male mi

Statins are highly effective in reducing plasma LDL-cholesterol but may be myotoxic. Since the relationship between statin exposure and myotoxicity...

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    [title] => Relationship between simvastatin pharmacokinetics and muscle toxicity in male mi
    [paragraph] => Relationship between simvastatin pharmacokinetics and muscle toxicity in male mice
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Authors
Jamal Bouitbir, Gerda M. Sanvee, Miljenko V. Panajatovic, Natasha Bärenzung Fehrenbach, Théo Fréchard, Madhuri Manivannan, Urs Duthaler, Stephan Krähenbühl



 Lab


Journal
Food and Chemical Toxicology


Abstract
Statins are highly effective in reducing plasma LDL-cholesterol but may be myotoxic. Since the relationship between statin exposure and myotoxicity is…


Keywords/Topics
Simvastatin;Skeletal muscle;Dose-finding study;Pharmacokinetics;Exercise;Atrophy
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.


Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)


Instrument for ratsInstrument for mice

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