Publications

Dernière publication 10/09/2018

Cysteamine Potentiates the Anti-Depressive Effects of Venlafaxine in Corticoster

The hypothalamic-pituitary-adrenal (HPA) axis abnormalities have been linked to the occurrence of severe depressive and anxiety states....

Array
(
    [id_prestablog_news] => 1069
    [id_shop] => 1
    [date] => 2018-09-10 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2100
    [id_lang] => 2
    [title] => Cysteamine Potentiates the Anti-Depressive Effects of Venlafaxine in Corticoster
    [paragraph] => Cysteamine Potentiates the Anti-Depressive Effects of Venlafaxine in Corticosterone-Induced Anxiety/Depression Mouse Model: Effect on Brain-Derived Neurotrophic
    [content] => 
Authors
E Ahmed, MK Tawfik, SS Essawy, AS Ahmed et al

 Lab
Neuropharmacology Group, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium
Journal
Egyptian Journal of Basic and Clinical Pharmacology
Abstract
The hypothalamic-pituitary-adrenal (HPA) axis abnormalities have been linked to the occurrence of severe depressive and anxiety states. Venlafaxine, a serotonin and a noradrenaline reuptake inhibitor (SNRI), is an approved antidepressant agent with evidence of non-response to treatment in a subset of patients. In this study, 48 male mice (30-38 g) were used to evaluate the possible anxiolytic and antidepressant in_uence of intraperitoneal (i.p.) cysteamine (150 mg/kg/day) on i.p. venlafaxine (10mg/Kg and 20mg/Kg), as well as e_ects on brain-derived neurotrophic factor (BDNF) level and tropomyosin-related kinase B (TrkB) gene expression in prefrontal cortex (PFC) in corticosterone-induced anxiety/depression mouse model. The present results provided evidence on insu_cient venlafaxine anxiolytic and antidepressant e_ects in this model. However, cysteamine combined with venlafaxine caused signi_cant antidepressant behavioral e_ects together with a signi_cant increase in BDNF levels followed by TrkB receptor downregulation in mice PFC. In conclusion, we highlight the potential use of a combination therapy of venlafaxine and cysteamine as a therapeutic strategy for glucocorticoid-related symptoms of depression
BIOSEB Instruments Used
Forced Swimming Test: New FST DUAL SENSOR (BIO-FST-DSM)
    [meta_description] => 
    [meta_keywords] => https://www.researchgate.net/publication/327353478_Cysteamine_Potentiates_the_Anti-Depressive_Effects_of_Venlafaxine_in_Corticosterone-Induced_AnxietyDepression_Mouse_Model_Effect_on_Brain-Derived_Neurotrophic_Factor_and_Tropomyosin-Related_Kinase_B
    [meta_title] => 
    [link_rewrite] => cysteamine-potentiates-the-anti-depressive-effects-of-venlafaxine-in-corticosterone-induced-anxiety-and-depression-mouse-model--effect-on-brain-derived-neurotrophic
    [actif_langue] => 1
    [read] => 962
    [count_comments] => 0
    [id] => 1069
    [categories] => Array
        (
            [57] => Array
                (
                    [id_prestablog_categorie] => 57
                    [title] => Dépression
                    [link_rewrite] => Depression
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [15] => Array
                (
                    [id_prestablog_categorie] => 15
                    [title] => Troubles de l'humeur
                    [link_rewrite] => Troubles-de-l-humeur
                )

        )

    [authors] => 
    [paragraph_crop] => Cysteamine Potentiates the Anti-Depressive Effects of Venlafaxine in Corticosterone-Induced [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [973] => Array
                (
                    [name] => Test de Nage Forcée: Nouveau FST DUAL SENSOR
                    [description_short] => 
Le nouveau Test de Nage Forcée Bioseb DUAL SENSOR à été développé selon une double approche:
En combinant une double acquisition, vibrations et trace vidéo,
 l'algorithme TYC (Train-Your-Computer) compare les deux sources capteur pour déterminer en temps réel le comportement de l'animal, rendant les résultats complètement indépendants de l'opérateur.

Le gestionnaire d'expériences, le module d'analyse, les possibilités de relecture et l'algorithme TYC sont parmi les fonctionnalités qui font du FST DUAL SENSOR un instrument très innovant et facile d'utilisation pour les études sur rats et souris (jusqu'à 4 animaux à la fois) pour automatiser le test de Porsolt, ou test de désespoir comportemental.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/anxiete-depression/973-forced-swimming-test-new-fst-dual-sensor.html
                )

        )

)
1