Système moteur - page 2 - Publications Scientifiques

Dernière publication 16/06/2017

IFN-β-induced reactive oxygen species and mitochondrial damage contribute to mus

Dermatomyositis (DM) is an autoimmune disease associated with enhanced type I interferon (IFN) signalling in skeletal muscle, but the mechanisms...

Array
(
    [id_prestablog_news] => 904
    [id_shop] => 1
    [date] => 2017-06-16 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 1772
    [id_lang] => 2
    [title] => IFN-β-induced reactive oxygen species and mitochondrial damage contribute to mus
    [paragraph] => IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis
    [content] => 
Authors
A. Meyer, G. Laverny, Y. Allenbach, E. Grelet, V. Ueberschlag, A. Echaniz-Laguna, B. Lannes, G. Alsaleh, A. Charles, F. Singh, J. Zoll, E. Lonsdorfer, F. Maurier, O. Boyer, J. E. Gottenberg, A. S. Nicot, J. Laporte, O. Benveniste, D. Metzger, J. Sibilia, B. Geny  Gottenberg JE12,4, Nicot AS4,5, Laporte J4,5, Benveniste O6, Metzger D4,5, Sibilia J12,4, Geny B9,4.  Lannes B8, Alsaleh G4, Charles AL9,4, Singh F9,4, Zoll J9,4, Lonsdorfer E9,4, Maurier F10, Boyer O11,  Gottenberg JE1

 Lab
Hôpitaux Universitaires de Strasbourg,  Institut de Physiologie, Strasbourg, France
Journal
Acta Neuropathologica: Pathology and Mechanisms of Neurological Disease
Abstract
Dermatomyositis (DM) is an autoimmune disease associated with enhanced type I interferon (IFN) signalling in skeletal muscle, but the mechanisms underlying muscle dysfunction and inflammation perpetuation remain unknown. Transcriptomic analysis of early untreated DM muscles revealed that the main cluster of down-regulated genes was mitochondria-related. Histochemical, electron microscopy, and in situ oxygraphy analysis showed mitochondrial abnormalities, including increased reactive oxygen species (ROS) production and decreased respiration, which was correlated with low exercise capacities and a type I IFN signature. Moreover, IFN-β induced ROS production in human myotubes was found to contribute to mitochondrial malfunctions. Importantly, the ROS scavenger N-acetyl cysteine (NAC) prevented mitochondrial dysfunctions, type I IFN-stimulated transcript levels, inflammatory cell infiltrate, and muscle weakness in an experimental autoimmune myositis mouse model. Thus, these data highlight a central role of mitochondria and ROS in DM. Mitochondrial dysfunctions, mediated by IFN-β induced-ROS, contribute to poor exercise capacity. In addition, mitochondrial dysfunctions increase ROS production that drive type I IFN-inducible gene expression and muscle inflammation, and may thus self-sustain the disease. Given that current DM treatments only induce partial recovery and expose to serious adverse events (including muscular toxicity), protecting mitochondria from dysfunctions may open new therapeutic avenues for DM.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)

Keywords/Topics
Déficits moteurs; Fonctions squelettales; Système moteur; Système musculaire; Maladies auto-immunes; Exercice & Endurance
    [meta_description] => 
    [meta_keywords] => https://link.springer.com/article/10.1007/s00401-017-1731-9
    [meta_title] => 
    [link_rewrite] => ifn--induced-reactive-oxygen-species-and-mitochondrial-damage-contribute-to-muscle-impairment-and-inflammation-maintenance-in-dermatomyositis
    [actif_langue] => 1
    [read] => 1196
    [count_comments] => 0
    [id] => 904
    [categories] => Array
        (
            [54] => Array
                (
                    [id_prestablog_categorie] => 54
                    [title] => Déficits moteurs
                    [link_rewrite] => Déficits-moteurs
                )

            [101] => Array
                (
                    [id_prestablog_categorie] => 101
                    [title] => Exercice & Endurance
                    [link_rewrite] => Exercice-et-Endurance
                )

            [64] => Array
                (
                    [id_prestablog_categorie] => 64
                    [title] => Fonctions squelettales
                    [link_rewrite] => Fonctions-squelettales
                )

            [98] => Array
                (
                    [id_prestablog_categorie] => 98
                    [title] => Maladies auto-immunes
                    [link_rewrite] => Maladies-auto-immunes
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [14] => Array
                (
                    [id_prestablog_categorie] => 14
                    [title] => Système moteur
                    [link_rewrite] => Systeme-moteur
                )

            [20] => Array
                (
                    [id_prestablog_categorie] => 20
                    [title] => Système musculaire
                    [link_rewrite] => Systeme-musculaire
                )

        )

    [authors] => 
    [paragraph_crop] => IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment  [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

        )

)
1