Authors
C. Huesa, L. Dunning, K. MacDougall, A. Ortiz, M. Villaluz, M. Fegen, A. Crilly, G. Litherland, R. van t Hof, C. Goodyear, J.C. Lockhart
Lab
Univ. of the West of Scotland, Glasgow, United Kingdom
Journal
Osteoarthritis and Cartilage
Abstract
International guidelines recommend exercise to delay rapid progression of osteoarthritis (OA). Numerous studies have shown that land-based exercise regimes, when performed regularly, leads to an improvement in joint mobility and pain. In vivo models of OA mimic many of the parameters of post-traumatic human OA. Destabilization of the medial meniscus (DMM) in rodents results in progressive development of OA with cartilage damage, osteosclerosis, mild synovitis, ligament damage/calcification and osteophyte formation.
BIOSEB Instruments Used:
Activmeter (BIO-ACTIV-R)