Activity, Motor Control & Coordination
Pain - Thermal Allodynia / Hyperalgesia
Pain - Spontaneous Pain - Postural Deficit
Pain - Mechanical Allodynia / Hyperalgesia
Anxiety & Depression Disorder
Learning/Memory - Attention - Addiction
Physiology & Respiratory Research
Metabolism - Food & Drink Intake
Pain
Central Nervous System (CNS)
Neurodegeneration
Sensory system
Motor control
Mood Disorders
Other disorders
Muscular system
Joints
Metabolism
Cross-disciplinary subjects
Preclinical studies and opioids: role in crisis management in the United States Authors
MS Berke, KSP Abelson
Lab
Department of Experimental Medicine, Copenhagen N, Denmark
Journal
Scandinavian Journal of Laboratory Animal Science
Abstract
This study investigated welfare, mechanical hyperalgesia and model specific parameters (mobility, stance, joint stiffness and ambulation impairment) during a three-week period in a rat model of monoarthritis. The objective was to identify possible targets for refinement of the model and consequently improve animal welfare. Monoarthritis was induced in eight male Sprague-Dawley rats by an intra-articular injection of 20 microL Complete Freund
BIOSEB Instruments Used:
Electronic Von Frey 4 (BIO-EVF4),Electronic Von Frey 5 with embedded camera (BIO-EVF5)
