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Dernière publication 12/09/2012

GluN2D Subunit-Containing NMDA Receptors Control Tissue Plasminogen Activator-Me

Tissue plasminogen activator (tPA) is a serine protease with pleiotropic actions in the CNS, such as synaptic plasticity and neuronal death. Some...

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    [title] => GluN2D Subunit-Containing NMDA Receptors Control Tissue Plasminogen Activator-Me
    [paragraph] => GluN2D Subunit-Containing NMDA Receptors Control Tissue Plasminogen Activator-Mediated Spatial Memory
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Authors
Pauline Obiang, Richard Macrez, Amandine Jullienne, Thomas Bertrand, Flavie Lesept, Carine Ali, Eric Maubert, Denis Vivien, and Véronique Agin



 Lab
INSERM, Caen, France


Journal
The Journal of Neuroscience


Abstract
Tissue plasminogen activator (tPA) is a serine protease with pleiotropic actions in the CNS, such as synaptic plasticity and neuronal death. Some effects of tPA require its interaction with the GluN1 subunit of the NMDA receptor (NMDAR), leading to a potentiation of NMDAR signaling. We have reported previously that the pro-neurotoxic effect of tPA is mediated through GluN2D subunit-containing NMDARs. Thus, the aim of the present study was to determine whether GluN2D subunit-containing NMDARs drive tPA-mediated cognitive functions. To address this issue, a strategy of immunization designed to prevent the in vivo interaction of tPA with NMDARs and GluN2D-deficient mice were used in a set of behavioral tasks. Altogether, our data provide the first evidence that tPA influences spatial memory through its preferential interaction with GluN2D subunit-containing NMDARs.
BIOSEB Instruments Used
Startle and Fear System (BX-START&FEAR)


Keywords/Topics
Domaines de recherche divers
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Instrument for ratsInstrument for mice

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