Publications

Dernière publication 15/10/2019

Trichloroethylene and its metabolite TaClo lead to degeneration of substantia ni

ParkinsonÕs disease (PD) is characterised pathologically by degeneration of the dopaminergic (DA) neurones of the substantia nigra pars compacta...

Array
(
    [id_prestablog_news] => 1157
    [id_shop] => 1
    [date] => 2019-10-15 00:00:00
    [date_modification] => 2024-02-09 14:15:12
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [prim_key] => 2274
    [id_lang] => 2
    [title] => Trichloroethylene and its metabolite TaClo lead to degeneration of substantia ni
    [paragraph] => Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra dopaminergic neurones: Effects in wild type and human A30P mutant alpha-synuclein mice
    [content] => 
Authors
PC Keane, PS Hanson, L Patterson, PG Blain et al

 Lab
Institute for Neuroscience, Newcastle University, Cookson Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Journal
Neuroscience Letters
Abstract
ParkinsonÕs disease (PD) is characterised pathologically by degeneration of the dopaminergic (DA) neurones of the substantia nigra pars compacta (SNpc) and the presence of alpha-synuclein containing Lewy body inclusions. Trichloroethylene (TCE) has been suggested as a potential environmental chemical that may contribute to the development of PD, via conversion to the neurotoxin, 1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo). We investigated the effect of an 8 week exposure to TCE or TaClo on wild type and, as an experimental model of PD, A30P mutant alpha-synuclein overexpressing mice using a combination of behaviour and pathology. TCE or TaClo exposure caused significant DA neuronal loss within the SNpc in both wild type and transgenic mice. Cell numbers were lower in A30P animals than wild type, however, no additive effect of TCE or TaClo exposure and A30P overexpression was found. TCE or TaClo did not appear to lead to acceleration of motor or cognitive deficits in either wild type or A30P mutant mice, potentially because of the modest reductions of DA neuronal number in the SNpc. Our results do however suggest that TCE exposure could be a possible factor in development of PD like changes following exposure.
BIOSEB Instruments Used
Grip strength test (BIO-GS3)
    [meta_description] => 
    [meta_keywords] => https://www.sciencedirect.com/science/article/pii/S0304394019305403
    [meta_title] => 
    [link_rewrite] => trichloroethylene-and-its-metabolite-taclo-lead-to-degeneration-of-substantia-nigra-dopaminergic-neurones--effects-in-wild-type-and-human-a30p-mutant-alpha-synuclein-mice
    [actif_langue] => 1
    [read] => 992
    [count_comments] => 0
    [id] => 1157
    [categories] => Array
        (
            [45] => Array
                (
                    [id_prestablog_categorie] => 45
                    [title] => Maladie de Parkinson
                    [link_rewrite] => Maladie-de-Parkinson
                )

            [12] => Array
                (
                    [id_prestablog_categorie] => 12
                    [title] => Neurodégénérescence
                    [link_rewrite] => Neurodegenerescence
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Trichloroethylene and its metabolite TaClo lead to degeneration of substantia nigra [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

        )

)
1