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Dernière publication 05/03/2026

IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsu

Globally, IS causes significant morbidity and is a leading cause of death (Lian et al., 2025;Ding et al., 2022). The pathophysiology of IS involves...

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    [title] => IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsu
    [paragraph] => IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsule in alleviating synaptic dysfunction in a murine model of cerebral ischemia and reperfusion injury
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Authors
Ke Song, Hongrui Zhang, Haoqi Liu, Yuanyuan Li, Yikun Sun, Xinglu Dong, Chenxi Tao, Yannan He, Zhenhong Liu, Yonghong Gao, Ying Gao

 Lab
Edited by: Yunyao Jiang; Tsinghua University; China; Reviewed by: Sadaf Jahan; Majmaah University; Saudi Arabia; Soad Zakaria; October 6 University; Egypt
Journal
Frontiers in Pharmacology
Abstract
Globally, IS causes significant morbidity and is a leading cause of death (Lian et al., 2025;Ding et al., 2022). The pathophysiology of IS involves complex events, including oxidative stress, inflammation, autophagy, ferroptosis, and apoptosis (Cai et al., 2025;Liu Y. et al., 2025;Liu L. et al., 2025;Zhao H. et al., 2025). Emerging evidence demonstrates that lncRNAs, including ANRIL, MALAT1, and H19, play regulatory functions in these processes during IS (Ding et al., 2025;He P. et al., 2025;Pan et al., 2024). lncRNAs, characterized as transcripts lacking protein-coding potential, actively participate in essential biological processes through transcriptional regulation and post-transcriptional modulation of gene expression (Degirmenci et al., 2019). Numerous studies have demonstrated the therapeutic efficacy of NST in IS, including anti-inflammatory and anti-apoptosis effects, and reduction of cerebral infarction area (Zhang et al., 2019;Luo et al., 2020;Li et al., 2021). It is noteworthy that while prior studies, including work by our team (Xu T. et al., 2025) and others (Luo et al., 2020), have explored a range of doses (e.g., 0.468, 0.936, and up to 1.872 g/kg in Luo et al.), the present study focused specifically on the clinically equivalent dose of 0.468 g/kg. This dose was selected based on body surface area conversion and its established efficacy in ameliorating core pathological features of IS in models. We note that the administration of significantly higher doses (e.g., 1 g/kg/day and above, as occasionally reported in exploratory pharmacological literature) may increase the risk of non-specific effects or artifacts, and such doses require rigorous justification. This study reinforces the evidence for the protective effect of NST treatment in ameliorating IS in mice subjected to cerebral ischemia-reperfusion (MCAO). Our findings validated the successful MCAO model: mice exhibited significant neurological deficits, decreased CBF perfusion, and damage to the cerebral cortex and neurons. We conclusively proved that NST effectively ameliorates brain ischemia/reperfusion injury. However, the exact molecular mechanisms underlying NST’s beneficial effects in IS remain unknown. Therefore, to examine these mechanisms, we conducted microarray analysis to identify differentially expressed genes in the cerebral cortex of MCAO mice following NST treatment.
Keywords/Topics
models; exploratory pharmacological literature; mice; mcao mice; transcriptomics; naoshuantong capsule; synaptic dysfunction; cerebral ischemia reperfusion injury; significant morbidity; death
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)
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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

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