Publications

Dernière publication 04/02/2015

Synthesis and Evaluation of New 1-5-Diaryl-3-[4--methyl-sulfonyl-phenyl]-4-5-dih

In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a-s were synthesized and evaluated for their antidepressant-like...

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    [title] => Synthesis and Evaluation of New 1-5-Diaryl-3-[4--methyl-sulfonyl-phenyl]-4-5-dih
    [paragraph] => Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
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Authors
Özdemir A, Alt?ntop MD, Kaplanc?kl? ZA, Can ÖD, Demir Özkay Ü, Turan-Zitouni G.

 Lab
Molecules
Journal
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, urkey
Abstract
In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2a-s were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test (MFST). The effects of the compounds on spontaneous locomotor activity were also investigated using an activity cage apparatus. Among these derivatives, compounds 2b, 2d, 2f, 2o, and 2r decreased both horizontal and vertical activity number of the mice. On the other hand, compounds 2a, 2h, 2j, 2k, 2l, 2m, and 2n, which did not induce any significant change in the locomotor activity, significantly shortened the immobility time of mice in TST and MFST, representing the presence of the antidepressant-like effect. Additionally, the same compounds increased the swimming time of mice in MFST without any change in climbing duration, similar to the reference drug fluoxetine (10 mg/kg). In the light of previous papers examining the effects of pyrazolines on central nervous system, this study, once more, pointed out remarkable antidepressant activity potential of pyrazoline derivatives.
BIOSEB Instruments Used
Tail Suspension Test - Wireless (BIO-TST5)

Keywords/Topics
Dépression; Troubles de l'humeur
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La version 5 du Test de Suspension Caudale de Bioseb, basée sur des capteurs de force ainsi que sur de l'acquisition vidéo, est la seule et unique solution totalement automatisée au monde pour effectuer un test de désespoir comportemental simple et objectif sur souris. Il s'agit d'une méthode rapide, fiable et sans douleur pour tester les effets psychotropes de drogues et substances comme les antidépresseurs et les sédatifs. Ce test classique et indolore pour la recherche sur l'anxiété et la dépression est désormais présenté avec un nouveau logiciel puissant et moderne, dans une version sans-fil BlueTooth.

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