Publications

Dernière publication 06/05/2009

The mechano-activated K channels TRAAK and TREK-1 control both warm and cold per

The sensation of cold or heat depends on the activation of specific nerve endings in the skin. This involves heat- and cold-sensitive excitatory...

Array
(
    [id_prestablog_news] => 625
    [id_shop] => 1
    [date] => 2009-05-06 00:00:00
    [date_modification] => 2024-02-09 14:15:11
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 1224
    [id_lang] => 2
    [title] => The mechano-activated K channels TRAAK and TREK-1 control both warm and cold per
    [paragraph] => The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception
    [content] => 
Authors
Jacques Noël, Katharina Zimmermann, Jérome Busserolles, et al.

 Lab
Université de Nice-Sophia Antipolis, CNRS, France
Journal
EMBO J.
Abstract
The sensation of cold or heat depends on the activation of specific nerve endings in the skin. This involves heat- and cold-sensitive excitatory transient receptor potential (TRP) channels. However, we show here that the mechano-gated and highly temperature-sensitive potassium channels of the TREK/TRAAK family, which normally work as silencers of the excitatory channels, are also implicated. They are important for the definition of temperature thresholds and temperature ranges in which excitation of nociceptor takes place and for the intensity of excitation when it occurs. They are expressed with thermo-TRP channels in sensory neurons. TRAAK and TREK-1 channels control pain produced by mechanical stimulation and both heat and cold pain perception in mice. Expression of TRAAK alone or in association with TREK-1 controls heat responses of both capsaicin-sensitive and capsaicin-insensitive sensory neurons. Together TREK-1 and TRAAK channels are important regulators of nociceptor activation by cold, particularly in the nociceptor population that is not activated by menthol.
BIOSEB Instruments Used
Cold Hot Plate Test (BIO-CHP),Thermal Place Preference, 2 Temperatures Choice Nociception Test (BIO-T2CT)

Keywords/Topics
Perception du chaud et du froid; Système sensoriel
    [meta_description] => 
    [meta_keywords] => http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683043/
    [meta_title] => 
    [link_rewrite] => the-mechano-activated-k-channels-traak-and-trek-1-control-both-warm-and-cold-perception
    [actif_langue] => 1
    [read] => 1160
    [count_comments] => 0
    [id] => 625
    [categories] => Array
        (
            [48] => Array
                (
                    [id_prestablog_categorie] => 48
                    [title] => Perception du chaud et du froid
                    [link_rewrite] => Perception-du-chaud-et-du-froid
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

            [13] => Array
                (
                    [id_prestablog_categorie] => 13
                    [title] => Système sensoriel
                    [link_rewrite] => Systeme-sensoriel
                )

        )

    [authors] => 
    [paragraph_crop] => The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [563] => Array
                (
                    [name] => Plaque froid et chaud
                    [description_short] => 
Instrument de test de la sensibilité de l'animal à la douleur résultant de l'exposition à la chaleur ou au froid: la plaque froid et chaud de Bioseb est un instrument innovant ouvrant de nouveaux champs d'investigation pour vos recherches en analgésie et nociception, et un outil efficace pour le screening de substances analgésiques basé sur les modèles de rat ou souris.

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-thermique/563-cold-hot-plate-test.html
                )

            [897] => Array
                (
                    [name] => Préférence de Place Thermique : Test de Choix entre 2 Températures
                    [description_short] => 
Un test indépendant de l'opérateur pour étudier les seuils de douleur chez les rongeurs (rats et souris) par l'évaluation de la préférence de température (zone de confort thermal) - un outil innovant pour vos recherches sur l'analgésie et la nociception, ouvrant de nouveaux champs d'étude, et une solution idéale pour le screening de médicaments analgésiques et nociceptifs. Désormais fourni avec un nouveau logiciel dernier cri permettant de monitorer l'activité et les transitions de température rapides!

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/douleur-allodyniehyperalgesie-thermique/897-thermal-place-preference-2-temperatures-choice-nociception-test.html
                )

        )

)
1