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Dernière publication 01/04/2025

Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyper

Frailty is characterized by an increased vulnerability to disease and physical debilitation due to a decline in the body’s capacity to...

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    [title] => Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyper
    [paragraph] => Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models
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Authors
Pyeong Geun Choi, Hee Soo Kim, So-Hyun Park, Hyo-Deok Seo, Jeong-Hoon Hahm, Yang Hoon Huh, Tae-Il Jeon, Jiyun Ahn, Chang Hwa Jung



 Lab


Journal
Journal of Advanced Research


Abstract
Frailty is characterized by an increased vulnerability to disease and physical debilitation due to a decline in the body’s capacity to maintain homeos…


Keywords/Topics
Aging;Caenorhabditis elegans;Health span;Longevity;Sarcopenia;Skeletal muscle
BIOSEB Instruments Used:
Grip strength test (BIO-GS4)

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Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.


Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)


Instrument for ratsInstrument for mice

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