Publications

Dernière publication 20/03/2021

Alpha‐lipoic acid supplementation increases the efficacy of exercise‐ and diet‐i

The decrease in the regulatory T cells (Tregs) population is highly involved in adipose tissue inflammation and insulin resistance in obesity....

Array
(
    [id_prestablog_news] => 1454
    [id_shop] => 1
    [date] => 2021-03-20 00:00:00
    [date_modification] => 2024-02-09 14:15:13
    [langues] => ["1","2"]
    [actif] => 1
    [slide] => 0
    [url_redirect] => 
    [average_rating] => 
    [number_rating] => 
    [author_id] => 1
    [featured] => 0
    [ishero] => 0
    [prim_key] => 3115
    [id_lang] => 2
    [title] => Alpha‐lipoic acid supplementation increases the efficacy of exercise‐ and diet‐i
    [paragraph] => Alpha‐lipoic acid supplementation increases the efficacy of exercise‐ and diet‐induced obesity treatment and induces immunometabolic changes in female mice and women
    [content] => 
Authors
S Le Garf, B Sibille, I Mothe-Satney, et al

 Lab
INSERM, C3M, Université Cote d'Azur, Nice, France
Journal
The FASEB Journal
Abstract
The decrease in the regulatory T cells (Tregs) population is highly involved in adipose tissue inflammation and insulin resistance in obesity. Tregs depend on fatty acids via beta-oxidation for immunosuppressive function adapting their antioxidant systems to allow survival to oxidative stress. In this study, we have hypothesized that a dietary supplementation with alpha-lipoic acid (ALA), a powerful antioxidant, would improve immunometabolism when added to the classical strategy of obesity treatment. First, we showed by in vitro experiments that ALA favors the polarization of mice CD4 + T cells toward Tregs. Next, we have carried out a translational study where female obese mice and women were supplemented with ALA or vehicle/placebo (mice: 2.5 gALA /kgfood ; 6 weeks; women: 600 mgALA /day, 8 weeks) while following a protocol including regular exercise and a change in diet. Fatty acid oxidation potential and activity of nuclear erythroid-related factor 2 (NRF2) of mouse secondary lymphoid tissues were improved by ALA supplementation. ALA reduced visceral adipose tissue (VAT) mass and preserved Tregs in VAT in mice. In women, ALA supplementation induced significant metabolic changes of circulating CD4 + T cells including increased oxidative capacity and fatty acid oxidation, ameliorated their redox status, and improved the reduction of visceral fat mass. While appropriate biological markers are still required to be used in clinics to judge the effectiveness of long-term obesity treatment, further studies in female mice and women are needed to determine whether these immunometabolic changes would reduce VAT mass-associated risk for secondary health issues arising from obesity.
BIOSEB Instruments Used
Grip strength test (BIO-GS3),Passive avoidance (LE870),Treadmill (BX-TM)

Keywords/Topics
Exercice & Endurance; Obésité & Surpoids
    [meta_description] => 
    [meta_keywords] => http://dx.doi.org/10.1096/fj.202001817RR
    [meta_title] => 
    [link_rewrite] => alphalipoic-acid-supplementation-increases-the-efficacy-of-exercise-and-dietinduced-obesity-treatment-and-induces-immunometabolic-changes-in-female-mice-and-women
    [actif_langue] => 1
    [read] => 328
    [count_comments] => 0
    [id] => 1454
    [categories] => Array
        (
            [101] => Array
                (
                    [id_prestablog_categorie] => 101
                    [title] => Exercice & Endurance
                    [link_rewrite] => Exercice-et-Endurance
                )

            [80] => Array
                (
                    [id_prestablog_categorie] => 80
                    [title] => Obésité & Surpoids
                    [link_rewrite] => Obesite-Surpoids
                )

            [2] => Array
                (
                    [id_prestablog_categorie] => 2
                    [title] => Publications
                    [link_rewrite] => publications
                )

        )

    [authors] => 
    [paragraph_crop] => Alpha‐lipoic acid supplementation increases the efficacy of exercise‐ and diet‐induced obesity  [...]
    [link_for_unique] => 1
    [products_liaison] => Array
        (
            [48] => Array
                (
                    [name] => Test d'agrippement
                    [description_short] => 
Une méthode simple pour quantifier objectivement la force musculaire des rats et souris et l'effet de drogues, toxines, maladies musculaires (ex: myopathie) et neurodégénératives. Cette mesure de force est souvent employée en association avec le test de coordination motrice ROTAROD: un sujet présentant une coordination normale montrera des résultats médiocres en cas de faible force musculaire. Un must pour vos recherches sur l'activité, la coordination et le contrôle musculaire: particulièrement utile pour vos études sur les maladies de Parkinson et Huntington.
Nouveautés GS4 - 2023: Écran couleur rétroéclairé (meilleure lisibilité), pédale de remise à zéro, durée de batterie optimisée, taille de mémoire augmentée à 500 valeurs, compteur d'animaux, port USB (transfert de données/charge)

                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/activite-systeme-moteur-coordination/48-grip-strength-test.html
                )

            [519] => Array
                (
                    [name] => Évitement passif
                    [description_short] => Test de motivation par la peur, classiquement utilisé 
pour évaluer la mémoire à long ou court terme 
sur de petits animaux de laboratoire
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/apprentissagememoire-attention-addiction/519-passive-avoidance.html
                )

            [61] => Array
                (
                    [name] => Tapis roulant
                    [description_short] => 
Conçu pour les études sur l'entraînement physique et la fatigue chez les rongeurs - et désormais livré avec un tout nouvel écran tactile sur la console de commande.
                    [thumb] => 
                    [img_empty] => /var/www/vhosts/de3310.ispfr.net/bioseb2024/modules/prestablog/views/img/product_link_white.jpg
                    [image_presente] => 1
                    [link] => https://bioseb.com/fr/activite-systeme-moteur-coordination/61-treadmill.html
                )

        )

)
1